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Type: Artigo
Title: Geant4 Monte Carlo Simulation Of Absorbed Dose And Radiolysis Yields Enhancement From A Gold Nanoparticle Under Mev Proton Irradiation
Author: Tran
H. N.; Karamitros
M.; Ivanchenko
V. N.; Guatelli
S.; McKinnon
S.; Murakami
K.; Sasaki
T.; Okada
S.; Bordage
M. C.; Francis
Z.; El Bitar
Z.; Bernal
M. A.; Shin
J. I.; Lee
S. B.; Barberet
Ph.; Tran
T. T.; Brown
J. M. C.; Hao
T. V. Nhan; Incerti
Abstract: Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Geant4-dna
Proton Beam
Radiation Therapy
Editor: Elsevier Science BV
Rights: fechado
Identifier DOI: 10.1016/j.nimb.2016.01.017
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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