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http://repositorio.unicamp.br/jspui/handle/REPOSIP/329538
Type: | Artigo |
Title: | Geant4 Monte Carlo Simulation Of Absorbed Dose And Radiolysis Yields Enhancement From A Gold Nanoparticle Under Mev Proton Irradiation Geant4 Monte Carlo simulation of absorbed dose and radiolysis yields enhancement from a gold nanoparticle under MeV proton irradiation |
Author: | Tran, H. N. Karamitros, M. Ivanchenko, V. N. Guatelli, S. McKinnon, S. Murakami, K. Sasaki, T. Okada, S. Bordage, M. C. Francis, Z. El Bitar, Z. Bernal, M. A. Shin, J. I. Lee, S. B. Barberet, P. Tran, T. T. Brown, J. M. C. Hao, T. V. N. Incerti, S. |
Abstract: | Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy. (C) 2016 Elsevier B.V. All rights reserved. Gold nanoparticles have been reported as a possible radio-sensitizer agent in radiation therapy due to their ability to increase energy deposition and subsequent direct damage to cells and DNA within their local vicinity. Moreover, this increase in energy deposition also results in an increase of the radiochemical yields. In this work we present, for the first time, an in silico investigation, based on the general purpose Monte Carlo simulation toolkit Geant4, into energy deposition and radical species production around a spherical gold nanoparticle 50 nm in diameter via proton irradiation. Simulations were preformed for incident proton energies ranging from 2 to 170 MeV, which are of interest for clinical proton therapy. |
Subject: | Geant4-dna Nanoparticle Radiolysis Proton Beam Radiation Therapy Geant4, DNA, Nanopartículas, Feixes de prótons, Radioterapia |
Country: | Holanda |
Editor: | Elsevier |
Citation: | Nuclear Instruments & Methods In Physics Research Section B-beam Interactions With Materials And Atoms. Elsevier Science Bv, v. 373, p. 126 - 139, 2016. |
Rights: | fechado |
Identifier DOI: | 10.1016/j.nimb.2016.01.017 |
Address: | https://www.sciencedirect.com/science/article/pii/S0168583X16000653 |
Date Issue: | 2016 |
Appears in Collections: | IFGW - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
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000374364900020.pdf | 6.43 MB | Adobe PDF | View/Open |
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