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Type: Artigo
Title: Copper(ii) Nitroaromatic Schiff Base Complexes: Synthesis, Biological Activity And Their Interaction With Dna And Albumins
Author: Martins
Darliane A.; Bomfim Filho
Lucius F.; da Silva
Cleiton M.; de Fatima
Angelo; Louro
Sonia R. W.; Batista
Denise G. J.; Soeiro
Maria de Nazare C.; de Carvalho
Joao Ernesto; Teixeira
Leticia R.
Abstract: Copper(II) complexes of the Schiff base ligands 2-((5-nitrofuran-2-yl)methyleneamino)phenol (HL1) and 2-(4-nitrobenzylideneamino)phenol (HL2) were prepared and characterized using physicochemical and spectroscopic techniques. In these complexes the Schiff base ligands acted as a bidentate donor bound to Cu2+ through the oxygen and nitrogen atoms in the deprotonated form. The electron paramagnetic resonance spectra, carried out on [CuCl(L1)(phen)]center dot 0.5H(2)O and [CuCl(L2)(phen)]center dot 2H(2)O complexes, showed the presence of only mononuclear forms. The Cu2+ complexes and ligands were evaluated for their in vitro trypanocidal activity. The complex [CuCl(L1)(phen)]center dot 0.5H(2)O was more active than the free Schiff base and also presented a superior effect to benznidazole, the reference drug. The antiproliferative activity of the Schiff bases and Cu2+ complexes were evaluated for their effect on seven tumor cell lines and showed a cytostatic and in some cases a cytotoxic effect. These compounds also presented binding properties to deoxyribonucleic acid (DNA) and moderate ability to quench the intrinsic fluorescence of albumins.
Subject: Schiff Base
Copper(ii) Complexes
Biological Activity
Editor: Soc Brasileira Quimica
São Paulo
Rights: aberto
Identifier DOI: 10.5935/0103-5053.20160150
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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