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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailr.paterno@me.com; fvonglehnsilva@bwh.harvard.edu; moraesadr@yahoo.com.br; vi_boldrini@hotmail.com; alfredodamasceno@hotmail.com; mdandrade43@gmail.com; allinydionete@yahoo.com.br; cristianecasanova@neurolife.com.br; charlespt@einstein.br; damascen@unicamp.br; leonilda@unicamp.br; carlosotavio@neurolife.com.brpt_BR
dc.typeArtigopt_BR
dc.titleMrzh Reaction Increases Sensitivity For Intrathecal Igg Synthesis In Igg Oligoclonal Band Negative Multiple Sclerosis Patientsen
dc.contributor.authorDias-Carneiropt_BR
dc.contributor.authorRafael P. C.; von Glehnpt_BR
dc.contributor.authorFelipe; Moraespt_BR
dc.contributor.authorAdriel S.; Boldrinipt_BR
dc.contributor.authorVinicius O.; Damascenopt_BR
dc.contributor.authorAlfredo; Andradept_BR
dc.contributor.authorMarilia D.; Limapt_BR
dc.contributor.authorAlliny C. D.; Casanovapt_BR
dc.contributor.authorCristiane S.; Tilberypt_BR
dc.contributor.authorCharles P.; Damascenopt_BR
dc.contributor.authorBenito P.; dos Santospt_BR
dc.contributor.authorLeonilda M. B.; Brandaopt_BR
dc.contributor.authorCarlos O.pt_BR
unicamp.authorBrandao, Carlos O.] Univ Estadual Campinas, Neuroimmunol Unit, Campinas, SP, Brazilpt_BR
unicamp.authorBrandao, Carlos O.] Univ Estadual Campinas, Dept Neurol, Campinas, SP, Brazilpt_BR
unicamp.author.external[Dias-Carneiro, Rafael P. C.pt_BR
unicamp.author.externalvon Glehn, Felipept_BR
unicamp.author.externalMoraes, Adriel S.pt_BR
unicamp.author.externalBoldrini, Vinicius O.pt_BR
unicamp.author.externalAndrade, Marilia D.pt_BR
unicamp.author.externalLima, Alliny C. D.pt_BR
unicamp.author.externalCasanova, Cristiane S.pt_BR
unicamp.author.externaldos Santos, Leonilda M. B.pt_BR
unicamp.author.external[Damasceno, Alfredopt_BR
unicamp.author.externalDamasceno, Benito P.pt_BR
unicamp.author.external[von Glehn, Felipe] Harvard Med Sch, Dept Neurol, Brigham & Womens Hosp, Ann Romney Ctr Neurol Dis, Boston, MA USApt_BR
unicamp.author.external[Dias-Carneiro, Rafael P. C.pt_BR
unicamp.author.externalTilbery, Charles P.] CATEM Multiple Sclerosis Care Ctr, Sao Paulo, Brazilpt_BR
dc.subjectMultiple Sclerosisen
dc.subjectCerebrospinal Fluiden
dc.subjectOligoclonal Bandsen
dc.subjectPolyspecific Antibodiesen
dc.subjectBrazilen
dc.subjectIntrathecal Synthesisen
dc.description.abstractGiven the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining lgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of lgG-OCB and/or >= MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone. (C) 2016 Elsevier B.V. All rights reserved.en
dc.relation.ispartofJournal of Neuroimmunologypt_BR
dc.publisherElsevier Science BVpt_BR
dc.publisherAmsterdampt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationnovpt_BR
dc.identifier.citationJournal Of Neuroimmunology . Elsevier Science Bv, v. 300, p. 30 - 35, 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume300pt_BR
dc.description.firstpage30pt_BR
dc.description.lastpage35pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn0165-5728pt_BR
dc.identifier.eissn1872-8421pt_BR
dc.identifier.wosidWOS:000388779500007pt_BR
dc.identifier.doi10.1016/j.jneuroim.2016.10.001pt_BR
dc.identifier.urlhttp://www.sciencedirect.com/science/article/pii/S0165572816303265?via%3Dihubpt_BR
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [2012/04565-0]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2017-11-13T13:54:44Z-
dc.date.accessioned2017-11-13T13:54:44Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:54:44Z (GMT). No. of bitstreams: 1 000388779500007.pdf: 246928 bytes, checksum: f7515014e1d14c41fa0e650991610e7f (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329484-
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