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Type: Artigo
Title: Mrzh Reaction Increases Sensitivity For Intrathecal Igg Synthesis In Igg Oligoclonal Band Negative Multiple Sclerosis Patients
Author: Dias-Carneiro
Rafael P. C.; von Glehn
Felipe; Moraes
Adriel S.; Boldrini
Vinicius O.; Damasceno
Alfredo; Andrade
Marilia D.; Lima
Alliny C. D.; Casanova
Cristiane S.; Tilbery
Charles P.; Damasceno
Benito P.; dos Santos
Leonilda M. B.; Brandao
Carlos O.
Abstract: Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining lgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of lgG-OCB and/or >= MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Multiple Sclerosis
Cerebrospinal Fluid
Oligoclonal Bands
Polyspecific Antibodies
Intrathecal Synthesis
Editor: Elsevier Science BV
Citation: Journal Of Neuroimmunology . Elsevier Science Bv, v. 300, p. 30 - 35, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.jneuroim.2016.10.001
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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