Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329484
Type: Artigo
Title: Mrzh Reaction Increases Sensitivity For Intrathecal Igg Synthesis In Igg Oligoclonal Band Negative Multiple Sclerosis Patients
MRZH reaction increases sensitivity for intrathecal IgG synthesis in IgG oligoclonal band negative Multiple Sclerosis patients
Author: Dias-Carneiro, Rafael P. C.
von Glehn, Felipe
Moraes, Adriel S.
Boldrini, Vinícius O.
Damasceno, Alfredo
Andrade, Marília D.
Lima, Alliny C. D.
Casanova, Cristiane S.
Tilbery, Charles P.
Damasceno, Benito P.
Santos, Leonilda
Abstract: Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigation of suspected MS. Paired CSF and sera were analyzed for IgG-OCB and polyspecific viral antibodies. IgG-OCB were detected in 72% of MS patients and an MRZH-reaction in 67%. Combining lgG-OCB and MRZH raised detection of IgG abnormalities to 97% of studied MS patients. Detection of lgG-OCB and/or >= MRZH antibodies showed sensitivity of 88% and specificity of 92% for MS, versus 72% and 96% for IgG-OCB alone. (C) 2016 Elsevier B.V. All rights reserved.
Given the low detection rates of CSF IgG-Oligoclonal bands (IgG-OCB) in non-European Multiple Sclerosis (MS) patients and higher specificity of the MRZH-reaction, we evaluated whether associating MRZH-reaction to CSF IgG-OCB detection improved investigati
Subject: Esclerose múltipla - Brasil
Líquido cefalorraquidiano
Bandas oligoclonais
Imunoglobulina G
Country: Países baixos
Editor: Elsevier
Citation: Journal Of Neuroimmunology . Elsevier Science Bv, v. 300, p. 30 - 35, 2016.
Rights: fechado
fechado
Identifier DOI: 10.1016/j.jneuroim.2016.10.001
Address: https://www.sciencedirect.com/science/article/pii/S0165572816303265
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos
FCM - Artigos e Outros Documentos

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