Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329412
Type: Artigo
Title: Ultrasound-promoted Synthesis Of 3-(thiophen-2-yl)-4,5-dihydro-1h-pyrazole-1carboximidamides And Anticancer Activity Evaluation In Leukemia Cell Lines
Author: dos Santos
Eric F. S.; Cury
Nathalia M.; do Nascimento
Tainara A.; Raminelli
Cristiano; Casagrande
Gleison A.; Pereira
Claudio M. P.; Simionatto
Euclesio; Yunes
Jose A.; Pizzuti
Lucas
Abstract: 3-(Thiophen-2-yl)-4,5-dihydro-1H-pyrazole-1-carboximidamides were efficiently prepared through a cyclocondensation of thiophenylchalcones with aminoguanidine hydrochloride under ultrasonic conditions in the presence of KOH and ethanol as a green solvent in short reaction times (15-35 min) and good yields (62-95%). All compounds produced were evaluated against the human Jurkat and RS4; 11 acute lymphoblastic leukemia cell lines of T- and B-cell origin, respectively, and the K562 myelogenous leukemia cell line. Six compounds presented half maximal inhibitory concentration (IC50) values around 15 mu mol L-1 and five compounds presented IC50 values around 40 mu mol L-1 for at least one of the three cell lines analyzed. One compound was not significantly cytotoxic, presenting IC50 value > 100 mu mol L- 1.
Subject: Amidinopyrazole
Pyrazoline
Cytotoxic Activity
Leukemia
Ultrasonic Irradiation
Editor: Soc Brasileira Quimica
São Paulo
Rights: aberto
Identifier DOI: 10.5935/0103-5053.20160166
Address: http://www.scielo.br/scielo.php?script=sci_abstract&pid=S0103-50532017000200217&lng=en&nrm=iso&tlng=en
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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