Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329088
Type: Artigo
Title: A Lipidomics Approach In The Characterization Of Zika-infected Mosquito Cells: Potential Targets For Breaking The Transmission Cycle
Author: Odir Rodrigues Melo
Carlos Fernando; de Oliveira
Diogo Noin; Lima
Estela de Oliveira; Guerreiro
Tatiane Melina; Esteves
Cibele Zanardi; Beck
Raissa Marques; Padilla
Marina Aiello; Milanez
Guilherme Paier; Arns
Clarice Weis; Proenca-Modena
Jose Luiz; Souza-Neto
Jayme Augusto; Catharino
Rodrigo Ramos
Abstract: Recent outbreaks of Zika virus in Oceania and Latin America, accompanied by unexpected clinical complications, made this infection a global public health concern. This virus has tropism to neural tissue, leading to microcephaly in newborns in a significant proportion of infected mothers. The clinical relevance of this infection, the difficulty to perform accurate diagnosis and the Small amount of data in literature indicate the necessity of studies on Zika infection in order to characterize new biomarkers of this infection and to establish new targets for viral control in vertebrates and invertebrate vectors. Thus, this study aims at establishing a lipidomics profile of infected mosquito cells compared to a control group to define potential targets for viral control in mosquitoes. Thirteen lipids were elected as specific markers for Zika virus infection (Brazilian strain), which were identified as putatively linked to the intracellular mechanism of viral replication and/or cell recognition. Our findings bring biochemical information that may translate into useful targets for breaking the transmission cycle.
Editor: Public Library Science
San Francisco
Rights: aberto
Identifier DOI: 10.1371/journal.pone.0164377
Address: http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0164377
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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