Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329074
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailljubica@iqm.unicamp.br; aciolylacerda@gmail.compt_BR
dc.typeArtigopt_BR
dc.titleNmr Spectroscopy Metabolomics Applied To Crack Cocaine Users And Patients With Schizophrenia: Similar Behavior But Different Molecular Causesen
dc.titleNMR spectroscopy metabolomics applied to crack cocaine users and patients with schizophrenia: similar behavior but different molecular causespt_BR
dc.contributor.authorTasic, Prof.Dr. Ljubicapt_BR
dc.contributor.authorPontes, João Guilherme de Moraespt_BR
dc.contributor.authorSouza, Rafael Nogueira dept_BR
dc.contributor.authorBrasil, Antonio Jadson Marreiropt_BR
dc.contributor.authorCruz, Guilherme Crispim de Fariapt_BR
dc.contributor.authorAsevedo, Prof.Dr. Elsonpt_BR
dc.contributor.authorDal Mas, Carolinept_BR
dc.contributor.authorPoppi, Prof.Dr. Ronei Jesuspt_BR
dc.contributor.authorBrietzke, Prof.Dr. Elisapt_BR
dc.contributor.authorHaypt_BR
unicamp.authorde Faria Cruz, Guilherme Crispim] Univ Estadual Campinas, Chem Inst, Dept Organ Chem, Lab Quim Biol, POB 6154, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.author[Poppi, Ronei Jesus] Univ Estadual Campinas, Chem Inst, Dept Analyt Chem, Lab Quimiometria Quim Analit, Campinas, SP, Brazilpt_BR
unicamp.author.external[Tasic, Ljubicapt_BR
unicamp.author.externalde Moraes Pontes, Joao Guilhermept_BR
unicamp.author.externalde Souza, Rafael Nogueirapt_BR
unicamp.author.externalMarreiro Brasil, Antonio Jadsonpt_BR
unicamp.author.external[Asevedo, Elsonpt_BR
unicamp.author.externalBrietzke, Elisapt_BR
unicamp.author.externalTavares Lacerda, Acioly Luiz] Univ Fed Sao Paulo, Dept Psychiat, Sao Paulo, SP, Brazilpt_BR
unicamp.author.external[Dal Mas, Carolinept_BR
unicamp.author.externalFuruie Hayashi, Mirian Akemi] Univ Fed Sao Paulo, Dept Pharmacol, Sao Paulo, SP, Brazilpt_BR
dc.subjectCrack-cocaineen
dc.subjectDrug Abuseen
dc.subjectMetabolomicsen
dc.subjectNmr-spectroscopyen
dc.subjectSchizophreniaen
dc.subjectCocaína crackpt_BR
dc.subjectDrogas - Abusopt_BR
dc.subjectMetabolômicapt_BR
dc.subjectEspectroscopia de ressonância magnética nuclearpt_BR
dc.subjectEsquizofreniapt_BR
dc.subject.otherlanguageCrack cocainept_BR
dc.subject.otherlanguageDrug abusept_BR
dc.subject.otherlanguageMetabolomicspt_BR
dc.subject.otherlanguageNuclear magnetic resonance spectroscopypt_BR
dc.subject.otherlanguageSchizophreniapt_BR
dc.description.abstractCrack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.en
dc.description.abstractCrack‐cocaine abuse and dependence is a severe public health problem. Sometimes, the crack‐cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crack‐cocaine use canpt_BR
dc.relation.ispartofChemistrySelectpt_BR
dc.publisher.cityWeinheimpt_BR
dc.publisher.countryAlemanhapt_BR
dc.publisherWileypt_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationApr.pt_BR
dc.identifier.citationChemistryselect. Wiley-v C H Verlag Gmbh, v. 2, p. 2927 - 2930, 2017.pt_BR
dc.language.isoengpt_BR
dc.description.volume2pt_BR
dc.description.issuenumber10pt_BR
dc.description.firstpage2927pt_BR
dc.description.lastpage2930pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn2365-6549pt_BR
dc.identifier.wosidWOS:000398582400007pt_BR
dc.identifier.doi10.1002/slct.201700009pt_BR
dc.identifier.urlhttps://onlinelibrary.wiley.com/doi/full/10.1002/slct.201700009pt_BR
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2014/18938-8]pt_BR
dc.description.sponsorshipConselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq) [454234/2014-7]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:45:41Z-
dc.date.accessioned2017-11-13T13:45:41Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:45:41Z (GMT). No. of bitstreams: 1 000398582400007.pdf: 1916089 bytes, checksum: b06ad958f54fc5c98bb349dae8051c31 (MD5) Previous issue date: 2017 Bitstreams deleted on 2021-01-06T12:26:44Z: 000398582400007.pdf,. Added 1 bitstream(s) on 2021-01-06T12:27:14Z : No. of bitstreams: 1 000398582400007.pdf: 1992271 bytes, checksum: 8de064f683a7447d83d11f05c1c84250 (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/329074-
dc.subject.keywordNMR spectroscopypt_BR
dc.type.formArtigopt_BR
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