Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/329074
Type: Artigo
Title: Nmr Spectroscopy Metabolomics Applied To Crack Cocaine Users And Patients With Schizophrenia: Similar Behavior But Different Molecular Causes
Author: Tasic
Ljubica; de Moraes Pontes
Joao Guilherme; de Souza
Rafael Nogueira; Marreiro Brasil
Antonio Jadson; de Faria Cruz
Guilherme Crispim; Asevedo
Elson; Dal Mas
Caroline; Poppi
Ronei Jesus; Brietzke
Elisa; Furuie Hayashi
Mirian Akemi; Tavares Lacerda
Acioly Luiz
Abstract: Crack-cocaine abuse and dependence is a severe public health problem. Sometimes, the crack-cocaine smokers show behavioral changes and symptoms very similar to those observed for severe mental disorders, like schizophrenia. Although crackcocaine use can easily be detected in smokers by urine or blood tests, after some time, cocaine biomarkers become untraceable. In addition, schizophrenia diagnosis is limited to clinical interviews, while precise clinical tests for this mental disorder remain unknown. Employing metabolomics based on NMR spectroscopy, herein, we showed that blood serum metabolites might be used for discrimination between crackcocaine users and schizophrenia patients groups. These two groups showed the greatest differences in around eleven keymetabolites. Moreover, seven possible peripheral metabolites might be enough for differentiation of crack-cocaine users and healthy controls. These results may contribute to a better understanding of crack-cocaine biochemical effects, and enable more precise diagnosis when crack-cocaine biomarkers, methylecgonidine or ecgonidine, are absent from the urine or blood of crack-cocaine users.
Subject: Crack-cocaine
Drug Abuse
Metabolomics
Nmr-spectroscopy
Schizophrenia
Editor: Wiley-V C H Verlag GMBH
Weinhem
Citation: Chemistryselect. Wiley-v C H Verlag Gmbh, v. 2, p. 2927 - 2930, 2017.
Rights: fechado
Identifier DOI: 10.1002/slct.201700009
Address: http://onlinelibrary.wiley.com/doi/10.1002/slct.201700009/abstract
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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