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Type: Artigo
Title: Anti-inflammatory And Antibothropic Properties Of Jatropha Elliptica, A Plant From Brazilian Cerrado Biome
Author: Ferreira-Rodrigues
Sara Costa; Rodrigues
Cassio Milhomens; Dos Santos
Marcio Galdino; Abraham Gautuz
Jean Antonio; Silva
Magali Glauzer; Cogo
Jose Carlos; Batista-Silva
Camila; Dos Santos
Cleiton Pita; Groppo
Francisco Carlos; Cogo-Mueller
Karina; Oshima-Franco
Abstract: The aim of this study was to evaluate the antibothropic and anti-inflammatory properties of J. elliptica. Methods: Phytochemical screening and thin-layer chromatography (TLC) assays were performed on J. elliptica hydroalcoholic extract (TE) in order to observe its main constituents. The antibothropic activity of TE was evaluated by the in vitro neuromuscular blockade caused by Bothrops jararacussu venom (Bjssu), in a mouse phrenic nerve-diaphragm model (PND). A quantitative histological study was carried out to observe a possible protection of TE against the venom myotoxicity. The anti-inflammatory activity was also evaluated in two models, Bjssu-induced paw edema, and carrageenan-induced neutrophils migration in the peritoneal cavity. Results: TLC analysis revealed several compounds in TE, such as saponins, alkaloids, and phenolic constituents. TE was able to neutralize the blockade and the myotoxicity induced by venom, when it was pre-incubated for 30 min with venom. In addition, it showed anti-inflammatory activity, inducing less neutrophils migration and reducing paw edema. Conclusion: J. elliptica showed both antibothropic and anti-inflammatory properties.
Subject: Bothrops Jararacussu
Jatropha Elliptica
Editor: Tabriz Univ Medical Sciences & Health Services
Citation: Advanced Pharmaceutical Bulletin. Tabriz Univ Medical Sciences & Health Services, v. 6, p. 573 - 579, 2016.
Rights: aberto
Identifier DOI: 10.15171/apb.2016.071
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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