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Type: Artigo
Title: St-elevation Myocardial Infarction Risk In The Very Elderly
Author: Campos
Alessandra M.; Placido-Sposito
Andrea; Freitas
Wladimir M.; Moura
Filipe A.; Guariento
Maria Elena; Nadruz Junior
Wilson; Moriguchi
Emilio H.; Sposito
Andrei C.
Abstract: Despite the high incidence and mortality of ST-segment elevation myocardial infarction (STEMI) among the very elderly, risk markers for this condition remain poorly defined. This study was designed to identify independent markers of STEMI among individuals carefully selected for being healthy or manifesting STEMI in <24 h. Methods: We enrolled participants aged 80 years or older of whom 50 were STEMI patients and 207 had never manifested cardiovascular diseases. Blood tests, medical and psychological evaluations were obtained at study admission. Odds Ratio (OR) and attributed risk (AR) were obtained by multivariate regression models using STEMI as dependent variable. Results: Low glomerular filtration rate (GFR) [OR: 4.41 (1.78-10.95); p = 0.001], reduced levels of HDL-C [OR: 10.70 (3.88-29.46); p = 0.001], male gender [OR: 12.08 (5.82-25.08); p = 0.001], moderate to severe depressive symptoms [OR: 10.00 (2.82-35.50); p = 0.001], prior smoking [OR: 2.00 (1.05-3.80); p = 0.034] and current smoking [OR: 6.58 (1.99-21.70); p= 0.002] were significantly associated with STEMI. No association was found between STEMI and age, diabetes, hypertension, mild depressive symptoms, triglyceride or LDL-C. Conclusions: This is the first case-control study carried out with very elderlies to assess STEMI risk. Our findings indicate that reduced HDL-C, GFR, male gender, smoking habits and moderate to severe depressive symptoms are markers of STEMI in this age group. General Significance: In Individuals aged 80 or more years, a greater attention must be paid to low HDL-C and GFR at the expense of conventional STEMI risk factors for younger adults such as diabetes mellitus, hypertension and high LDL-C or triglyceride. (C) 2016 The Authors. Published by Elsevier B.V.
Subject: Myocardial Infarction
Aged, 80 And Over
Editor: Elsevier Science BV
Citation: Bba Clinical. Elsevier Science Bv, v. 6, p. 108 - 112, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.bbacli.2016.09.001
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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