Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328965
Type: Artigo
Title: Intravenous Bisphosphonate Therapy Does Not Thicken Cementum Or Change Periodontal Ligaments Of Cancer Patients
Intravenous bisphosphonate therapy does not thicken cementum or change periodontal ligaments of cancer patients
Author: Paglioni, Mariana de Pauli
Silva, Wagner Gomes
Pereira, Juliana
Migliorati, Cesar Augusto
Lopes, Marcio Ajudarte
de Almeida, Oslei Paes
Goes, Mario Fernando
Prado Ribeiro, Ana Carolina
Brandão, Thais Bianca
Santos-Silva, Alan Roger
Abstract: To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Study Design. Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. Results. No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. Conclusion. IV BP therapy does not thicken cementum or change the micromorphology of PDL.
To test the hypothesis that intravenous (IV) bisphosphonate (BP) therapy thickens or alters the micromorphology of cementum and periodontal ligament (PDL) in cancer patients. Thirty-two teeth extracted from 24 cancer patients and separated into test (patients who have undergone IV BP therapy, n = 16) and control (patients naive to BP therapy, n = 16) groups were studied. Cementum thickness was measured in 3 different areas of the dental root with polarized light microscopy. PDL was assessed by optical light microscopy and the immunohistochemical expression of periostin. No significant difference was detected in cementum thickness (apical, P = .06; medium, P = .16; cervical, P = .18) between groups. The numbers of fibroblasts in PDL (P = .56), incremental lines of cementum (P = .51) and the immunohistochemical patterns of periostin expression in PDL (P = .68) did not differ between groups. IV BP therapy does not thicken cementum or change the micromorphology of PDL
Subject: Periostin-like-factor
Osteonecrosis
Jaw
Tooth
Mechanisms
Tissue
Rats
Ratos
Dentes
Osteonecrose
Country: Holanda
Editor: Elsevier
Citation: Oral Surgery Oral Medicine Oral Pathology Oral Radiology. Elsevier Science Inc, v. 123, p. 591 - 599, 2017.
Rights: fechado
Identifier DOI: 10.1016/j.oooo.2017.02.008
Address: https://www.sciencedirect.com/science/article/pii/S2212440317300676
Date Issue: 2017
Appears in Collections:FOP - Artigos e Outros Documentos

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