Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328822
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dc.contributor.CRUESPUNIVERSIDADE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authorunicampCésar, Carlos Lenzpt_BR
dc.typeArtigopt_BR
dc.titleMultimodal evaluation of ultra-short laser pulses treatment for skin burn injuriespt_BR
dc.contributor.authorSantos, M. O.pt_BR
dc.contributor.authorLatrive, A.pt_BR
dc.contributor.authorCastro, P. A. A.pt_BR
dc.contributor.authorRossi, W.pt_BR
dc.contributor.authorZorn, T. M. T.pt_BR
dc.contributor.authorSamad, R. E.pt_BR
dc.contributor.authorFreitas, A. Z.pt_BR
dc.contributor.authorCesar, C. L.pt_BR
dc.contributor.authorVieira Junior, N. D.pt_BR
dc.contributor.authorZezell, D. M.pt_BR
dc.subjectTomografia de coerência ópticapt_BR
dc.subjectTransformadas de Fourierpt_BR
dc.subjectMicroscopiapt_BR
dc.subject.otherlanguageTomography optical coherencept_BR
dc.subject.otherlanguageMicroscopypt_BR
dc.subject.otherlanguageFourier transformationspt_BR
dc.description.abstractThousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were non-invasively characterized by OCT images and biopsied for further histopathology analysis, SHG imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as efficient as the classical treatment for promoting the healing process. The study concludes to the validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of minimizing operatory trauma.pt
dc.description.abstractThousands of people die every year from burn injuries. The aim of this study is to evaluate the feasibility of high intensity femtosecond lasers as an auxiliary treatment of skin burns. We used an in vivo animal model and monitored the healing process using 4 different imaging modalities: histology, Optical Coherence Tomography (OCT), Second Harmonic Generation (SHG), and Fourier Transform Infrared (FTIR) spectroscopy. 3 dorsal areas of 20 anesthetized Wistar rats were burned by water vapor exposure and subsequently treated either by classical surgical debridement, by laser ablation, or left without treatment. Skin burn tissues were non-invasively characterized by OCT images and biopsied for further histopathology analysis, SHG imaging and FTIR spectroscopy at 3, 5, 7 and 14 days after burn. The laser protocol was found as efficient as the classical treatment for promoting the healing process. The study concludes to the validation of femtosecond ultra-short pulses laser treatment for skinburns, with the advantage of minimizing operatory trauma.pt_BR
dc.relation.ispartofBiomedical optics expresspt_BR
dc.relation.ispartofabbreviationBiomed. opt. expresspt_BR
dc.publisher.cityWashington, WApt_BR
dc.publisher.countryEstados Unidospt_BR
dc.publisherOptical Society of Americapt_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationMar.pt_BR
dc.identifier.citationBiomedical Optics Express. Optical Soc Amer, v. 8, p. 1575 - 1588, 2017.pt_BR
dc.language.isoengpt_BR
dc.description.volume8pt_BR
dc.description.issuenumber3pt_BR
dc.description.firstpage1575pt_BR
dc.description.lastpage1588pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.eissn2156-7085pt_BR
dc.identifier.doi10.1364/BOE.8.001575pt_BR
dc.identifier.urlhttps://www.osapublishing.org/boe/abstract.cfm?uri=boe-8-3-1575pt_BR
dc.description.sponsorshipCONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICO - CNPQpt_BR
dc.description.sponsorshipCOORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIOR - CAPESpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO - FAPESPpt_BR
dc.description.sponsorshipFUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZpt_BR
dc.description.sponsorship1FAPESP - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULOpt_BR
dc.description.sponsorship1CNPQ - CONSELHO NACIONAL DE DESENVOLVIMENTO CIENTÍFICO E TECNOLÓGICOpt_BR
dc.description.sponsorship1CAPES - COORDENAÇÃO DE APERFEIÇOAMENTO DE PESSOAL DE NÍVEL SUPERIORpt_BR
dc.description.sponsorship1FAPEAM - FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DO AMAZONASpt_BR
dc.description.sponsordocumentnumber05/51689-2; 11/51959-0pt_BR
dc.description.sponsordocumentnumber573.916/2008-0; 573.913/2008-00; 312397/2013-5pt_BR
dc.description.sponsordocumentnumber8881.068505/2014-01pt_BR
dc.description.sponsordocumentnumberSem informaçãopt_BR
dc.date.available2017-11-13T13:44:39Z-
dc.date.accessioned2017-11-13T13:44:39Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:44:39Z (GMT). No. of bitstreams: 1 000395942600024.pdf: 7334086 bytes, checksum: ac10a871f3e36b100df90bec44c1e82b (MD5) Previous issue date: 2017 Bitstreams deleted on 2020-07-03T19:06:43Z: 000395942600024.pdf,. Added 1 bitstream(s) on 2020-07-03T19:12:38Z : No. of bitstreams: 1 000395942600024.pdf: 7200805 bytes, checksum: c8265289e91a69381ff82e43ec1b5f2e (MD5)en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328822-
dc.contributor.departmentDepartamento de Eletrônica Quânticapt_BR
dc.contributor.unidadeInstituto de Física "Gleb Wataghin"pt_BR
dc.subject.keywordUltrafast laserspt_BR
dc.subject.keywordAblation of tissuept_BR
dc.identifier.source000395942600024pt_BR
dc.creator.orcidorcid.org/0000-0001-5573-9636pt_BR
dc.type.formArtigo de periódicopt_BR
dc.type.formArtigopt_BR
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