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dc.titleHypertriglyceridemic Waist Phenotype Indicates Insulin Resistance In Adolescents According To The Clamp Technique In The Brams Studyen
dc.contributor.authorFrancieli; Junqueira Vasquespt_BR
dc.contributor.authorAna Carolina; da Silvapt_BR
dc.contributor.authorCleliani de Cassia; Zambonpt_BR
dc.contributor.authorMariana Porto; De Bernardi Rodriguespt_BR
dc.contributor.authorAna Maria; Camilopt_BR
dc.contributor.authorDaniella Fernandes; de Goes Monteiro Antoniopt_BR
dc.contributor.authorMaria Angela Reis; Damasopt_BR
dc.contributor.authorAna Raimunda; da Silveira Campospt_BR
dc.contributor.authorRaquel Munhoz; Tufikpt_BR
dc.contributor.authorSergio; de Mellopt_BR
dc.contributor.authorMarco Tulio; Gelonezept_BR
unicamp.authorGeloneze, Bruno] Univ Campinas UNICAMP, LIMED Lab Invest Metab & Diabet, Gastroctr, Campinas, Brazilpt_BR
unicamp.authorGeloneze, Bruno] Univ Campinas UNICAMP, Sch Med Sci, Post Grad Program Child & Adolescent Hlth, Campinas, SP, Brazilpt_BR[Junqueira Vasques, Ana Carolina] Univ Campinas UNICAMP, Sch Appl Sci, Sao Paulo, Brazilpt_BR
unicamp.authorde Goes Monteiro Antonio, Maria Angela Reis] Univ Campinas UNICAMP, Dept Pediat, Sao Paulo, Brazilpt_BR[Barreiro-Ribeiro, Francielipt_BR Vasques, Ana Carolinapt_BR Silva, Cleliani de Cassiapt_BR Bernardi Rodrigues, Ana Mariapt_BR, Daniella Fernandespt_BR[Barreiro-Ribeiro, Francielipt_BR Vasques, Ana Carolinapt_BR Silva, Cleliani de Cassiapt_BR, Daniella Fernandespt_BR[Zambon, Mariana Portopt_BR[Damaso, Ana Raimunda] Fed Univ Sao Paulo UNIFESP, Post Grad Program Nutr, Sao Paulo, Brazilpt_BR[da Silveira Campos, Raquel Munhoz] Fed Univ Sao Carlos UFSCar, Dept Physiotherapy, Therapeut Resources Lab, Sao Carlos, SP, Brazilpt_BR[Tufik, Sergiopt_BR Mello, Marco Tulio] Fed Univ Sao Paulo UNIFESP, Dept Psychobiol, Sao Paulo, Brazilpt_BR
dc.subjectBeta-cell Functionen
dc.subjectMetabolic Triaden
dc.subjectObese Childrenen
dc.description.abstractThis study aimed to identify cutoff points for detecting hypertriglyceridemic waist phenotype (HTWP) in adolescents and to investigate the association of the HTWP with insulin resistance (IR) and metabolic syndrome components. Methods: A multicentric cross-sectional study of 861 adolescents (10-19 years of age, 504 girls) was conducted. Pubertal stage, anthropometric, and laboratory parameters were assessed. IR was assessed by Homeostasis Model Assessment for Insulin Resistance (HOMA1-IR) index and hyperglycemic clamp (n = 80). HTWP was defined by the presence of increased plasma triglycerides (TGs) and increased waist circumference (WC) according to cutoff points obtained in ROC curve analysis given the HOMA1-IR index as a reference method. Results: Cutoffs for WC and TGs, with a higher sum of sensitivity (S) and specificity (E), were, respectively: >84cm (S:65.1%, E:71.9%) and >87mg/dL (S:65.1%, E:73.4%) in pubertal girls; >88.5cm (S:80.2%, E:60.2%) and >78mg/dL (S:60.5%, E:53.2%) in postpubertal girls; >94cm (S:73.1%, E:83.1%) and >79mg/dL (S:61.5%, E:60.2%) in pubertal boys; and >99cm (S:81.3%, E:78.7%) and >86mg/dL in postpubertal boys (S:68.1%, E:60.7%). HTWP frequency was 27.5%. In the phenotype presence, after adjustment for age and pubertal stage, blood pressure and fasting glucose levels were elevated and high-density lipoprotein cholesterol was lower (p<0.001). Adolescents with the HTWP showed more IR, evaluated both by the HOMA1-IR and by the clamp test (p<0.003). Conclusion: The findings suggest HTWP as an IR status in adolescents. Cutoff point standardization for gender and pubertal stage, combined with the ease of application of the method, may allow their use for screening adolescents who would most benefit from lifestyle changes.en
dc.relation.ispartofChildhood Obesitypt_BR
dc.publisherMary Ann Liebert, Incpt_BR
dc.publisherNew Rochellept_BR
dc.identifier.citationChildhood Obesity. Mary Ann Liebert, Inc, v. 12, p. 446 - 454, 2016.pt_BR
dc.description.sponsorshipNational Council of Scientific and Technological Development (CNPq) [563664/2010-0]pt_BR
dc.description.sponsorshipCoordination for the Improvement of Higher Education Personnel (CAPES) [01-P-4346-2015]pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.provenanceMade available in DSpace on 2017-11-13T13:44:36Z (GMT). No. of bitstreams: 1 000388194200006.pdf: 486200 bytes, checksum: 64fa21c5c0b7dd209facfb6e18aa167d (MD5) Previous issue date: 2016en
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