Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328757
Type: Artigo
Title: Nanostructures For Protein Drug Delivery
Author: Pachioni-Vasconcelos
Juliana de Almeida; Lopes
Andre Moreni; Apolinario
Alexsandra Conceicao; Valenzuela-Oses
Johanna Karina; Ribeiro Costa
Juliana Souza; Nascimento
Laura de Oliveira; Pessoa
Adalberto
Jr.; Souza Barbosa
Leandro Ramos; Rangel-Yagui
Carlota de Oliveira
Abstract: Use of nanoscale devices as carriers for drugs and imaging agents has been extensively investigated and successful examples can already be found in therapy. In parallel, recombinant DNA technology together with molecular biology has opened up numerous possibilities for the large-scale production of many proteins of pharmaceutical interest, reflecting in the exponentially growing number of drugs of biotechnological origin. When we consider protein drugs, however, there are specific criteria to take into account to select adequate nanostructured systems as drug carriers. In this review, we highlight the main features, advantages, drawbacks and recent developments of nanostructures for protein encapsulation, such as nanoemulsions, liposomes, polymersomes, single-protein nanocapsules and hydrogel nanoparticles. We also discuss the importance of nanoparticle stabilization, as well as future opportunities and challenges in nanostructures for protein drug delivery.
Subject: Block-copolymer Micelles
In-vivo
Hydrogel Nanoparticles
Diblock Copolymers
Efficient Encapsulation
Chitosan Nanoparticles
Intestinal-absorption
Phospholipid-vesicles
Clinical-applications
Influenza Virosomes
Editor: Royal Soc Chemistry
Cambridge
Rights: fechado
Identifier DOI: 10.1039/c5bm00360a
Address: http://pubs.rsc.org/en/Content/ArticleHtml/2016/BM/c5bm00360a
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000368945400001.pdf3.01 MBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.