Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328732
Type: Artigo
Title: Synthesis Of Azo Carbonate Monomers And Biocompatibility Study Of Poly(azo-carbonate-urethane)s
Author: Capitao
R. M.; Santo
R. D. E.; Magalhaes
A.; Assis
D.; da Silva
G. V. J.; Scarim
C. B.; Chelucci
R. C.; Andrade
C. R.; Chung
M. C.; Gonzalez
E. R. P.
Abstract: The present work describes the synthesis of azo carbonate monomers by a clean carbonylation synthetic route using di-methylcarbonate. The kinetics study showed a conversion of similar to 98% to bis-carbonates after only six minutes of reaction using triazabicyclo[4.4.0]dec-5-ene (TBD) as the catalyst. The preparation of azo-carbonates by means of coupling aryldiazonium salts with bis-carbonate was performed. The reactivity of azo-carbonate monomers was tested in the polycondensation reaction with an aminoalcohol using TBD as a catalyst for the formation of non-isocyanate poly(azo-carbonate-urethane)s PCU 1 and PCU 2. The copolymers' structures were confirmed by FT-IR, NMR and MALDI experiments, which allow us to determine the different terminal groups of the polymer chains formed. The molecular weights and the molecular weight distribution of PCU 1 and PCU 2 were determined by size-exclusion chromatography (SEC) experiments and thermal stabilities were also studied by TG analysis. The biocompatible properties of monomers 4 and 6 and polymers PCU 1 and PCU 2 were investigated by liver, kidney and colon histological analyses.
Subject: Dimethyl Carbonate
In-vivo
Polymers
Intermediate
Methylation
Performance
Chemistry
Catalysis
Memory
Dbu
Editor: Royal Soc Chemistry
Cambridge
Citation: Rsc Advances. Royal Soc Chemistry, v. 6, p. 79987 - 79997, 2016.
Rights: aberto
Identifier DOI: 10.1039/c6ra11075d
Address: http://pubs.rsc.org/en/content/articlehtml/2016/RA/C6RA11075D
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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