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Type: Artigo
Title: Incidence And Duration Of Type-specific Human Papillomavirus Infection In High-risk Hpv-naive Women: Results From The Control Arm Of A Phase Ii Hpv-16/18 Vaccine Trial
Author: Ramanakumar
Agnihotram V.; Naud
Paulo; Roteli-Martins
Cecilia M.; de Carvalho
Newton S.; de Borba
Paola C.; Teixeira
Julio C.; Blatter
Mark; Moscicki
Anna-Barbara; Harper
Diane M.; Romanowski
Barbara; Tyring
Stephen K.; Ramjattan
Brian; Schuind
Anne; Dubin
Gary; Franco
Eduardo L.
Abstract: Persistence of human papillomaviruses (HPVs) is necessary for cervical carcinogenesis. We evaluated incidence and duration of type-specific HPV infections and the influence of age and number of sexual partners. Methods: Data were obtained from 553 women (15-25 years), who were seronegative and DNA-negative for high-risk HPV (HR-HPV) types and were enrolled in the placebo arm of a randomised trial of the HPV-16/ 18 vaccine (NCT00689741/NCT00120848). They were followed for 6.3 years. Cervicovaginal samples were self-collected at 3-month intervals for up to 27 months, and cervical samples were collected by clinicians at 6-month intervals until study end. Samples were tested for HPV types using a broad-spectrum PCR assay. Incidence rate ratios (RRs) and 95% CIs were used to estimate the association among age, sexual habits and HPV acquisition. Results: Incidence rates (95% CI) using cervical samples were 11.8 (10.4 to 13.4) and 5.6 (4.7 to 6.6) per 1000 women-months for HR-HPVs and low-risk HPVs (LR-HPVs), respectively. Equivalent rates in combined cervicovaginal and cervical samples were 17.2 (15.4 to 19.2) and 6.9 (5.9 to 8.0), respectively. 54 per cent of HR-HPV types from combined cervicovaginal and cervical samples persisted for 1 year compared with 32.3% for LR-HPV types. The risk of acquiring any HPV infection was higher among women aged <21 years (RR=1.33, 95% CI 1.1 to 1.7) and women having >1 sexual partner (RR=1.83, 95% CI 1.4 to 2.4) at baseline. Conclusions: HR-HPV infections were more common and lasted longer on average than LR-HPV infections. HPV acquisition was more common in younger women with multiple sexual partners.
Subject: Cervical Intraepithelial Neoplasia
Genital Human-papillomavirus
Cytologically Normal Women
Prospective Follow-up
Longitudinal Cohort
Particle Vaccine
Editor: BMJ Publishing Group
Rights: aberto
Identifier DOI: 10.1136/bmjopen-2016-011371
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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