Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328569
Type: Artigo
Title: Xpd C.934g > A Polymorphism Of Nucleotide Excision Repair Pathway In Outcome Of Head And Neck Squamous Cell Carcinoma Patients Treated With Cisplatin Chemoradiation
Xpd C.934g > a polymorphism of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma patients treated with cisplatin chemoradiation
Author: Lopes-Aguiar, Leisa
Costa, Ericka Francislaine Dias
Nogueira, Guilherme Augusto Silva
Lima, Tathiane Regine Penna
Visacri, Marilia Berlofa
Pincinato, Eder Carvalho
Calonga, Luciane
Mariano, Fernanda Viviane
Altemani, Albina Messias
Abstract: This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinoma (HNSCC) patients treated with cisplatin (CDDP) chemoradiation. Patients with XPC c.2815AC or CC and XPD c.934GA or AA genotypes had 0.20 and 0.38 less chances of presenting moderate/severe ototoxicity and nausea, respectively. Patients with XPD c.934AA and c.2251AC or CC genotypes had 8.64, 12.29 and 3.55 more chances of achieving complete response (CR), consistent ototoxicity and nephrotoxicity, respectively. AA haplotype of XPD and ACT haplotype of XPD and ERCC1 SNPs were associated with 9.30 and 3.41 more chances of achieving CR and consistent nephrotoxicity, respectively. At 24 months of follow-up, patients with XPD c.934AA genotype presented lower progression-free survival and overall survival in Kaplan-Meier estimates, and differences between groups remained the same in univariate Cox analysis. Patients with XPD c.934AA genotype had 2.13 and 2.04 more risks of presenting tumor progression and death than others in multivariate Cox analysis. Our data present preliminary evidence that XPC c.2815A>C, XPD c.934G>A and c.2251A>C, and ERCC1 c.354C>T SNPs alter outcome of HNSCC patients treated with CDDP chemoradiation.
This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinom
metadata.dc.description.abstractalternative: This study aimed to investigate the associations of XPC c.2815A>C, XPD c.934G>A and c.2251A>C, XPF c.2505T>C and ERCC1 c.354C>T single nucleotide polymorphisms (SNPs) of nucleotide excision repair pathway in outcome of head and neck squamous cell carcinom
Subject: Head And Neck Squamous Cell Carcinoma
Cisplatin
Nucleotide Excision Repair Pathway
Single Nucleotide Polymorphisms
Outcome
Carcinoma de células escamosas de cabeça e pescoço
Cisplatino
Polimorfismo de nucleotídeo único
Country: Estados Unidos
Editor: Impact Journals
Citation: Oncotarget. Impact Journals Llc, v. 8, p. 16190 - 16201, 2017.
Rights: aberto
Identifier DOI: 10.18632/oncotarget.7668
Address: http://www.impactjournals.com/oncotarget/index.php?journal=oncotarget&page=article&op=view&path[]=7668&pubmed-linkout=1
Date Issue: 2017
Appears in Collections:FCM - Artigos e Outros Documentos
FCF - Artigos e Outros Documentos

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