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Type: Artigo
Title: Sensitizing Mucoepidermoid Carcinomas To Chemotherapy By Targeted Disruption Of Cancer Stem Cells
Author: Guimaraes
Douglas M.; Almeida
Luciana O.; Martins
Manoela D.; Warner
Kristy A.; Silva
Alan R. S.; Vargas
Pablo A.; Nunes
Fabio D.; Squarize
Cristiane H.; Nor
Jacques E.; Castilho
Rogerio M.
Abstract: Mucoepidermoid carcinoma (MEC) is the most common malignancy of salivary glands. The response of MEC to chemotherapy is unpredictable, and recent advances in cancer biology suggest the involvement of cancer stem cells (CSCs) in tumor progression and chemoresistance and radioresistance phenotype. We found that histone acetyltransferase inhibitors (HDACi) were capable of disrupting CSCs in MEC. Furthermore, administration of HDACi prior to Cisplatin (two-hit approach) disrupts CSCs and sensitizes tumor cells to Cisplatin. Our findings corroborate to emerging evidence that CSCs play a key role in tumor resistance to chemotherapy, and highlights a pharmacological two-hit approach that disrupts tumor resistance to conventional therapy.
Subject: Salivary Cancer
Histone Modifications
Histone Acetylation
Cancer Initiating Cells
Editor: Impact Journals Llc
Citation: Oncotarget. Impact Journals Llc, v. 7, p. 42447 - 42460, 2016.
Rights: aberto
Identifier DOI: 10.18632/oncotarget.9884
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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