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Type: Artigo
Title: Viral Inhibition Mechanism Mediated By Surface-modified Silica Nanoparticles
Author: de Souza e Silva
Juliana Martins; Melo Hanchuk
Talita Diniz; Santos
Murilo Izidoro; Kobarg
Joerg; Bajgelman
Marcio Chaim; Cardoso
Mateus Borba
Abstract: Vaccines and therapies are not available for several diseases caused by viruses, thus viral infections result in morbidity and mortality of millions of people every year. Nanoparticles are considered to be potentially effective in inhibiting viral infections. However, critical issues related to their use include their toxicity and their mechanisms of antiviral action, which are not yet completely elucidated. To tackle these problems, we synthesized silica nanoparticles with distinct surface properties and evaluated their biocompatibility and antiviral efficacy. We show that nanoparticles exhibited no significant toxicity to mammalian cells, while declines up to 50% in the viral transduction ability of two distinct recombinant viruses were observed. We designed experiments to address the mechanism of antiviral action of our nanoparticles and found that their hydrophobic/hydrophilic characters play a crucial role. Our results reveal that the use of functionalized silica particles is a promising approach for controlling viral infection and offer promising strategies for viral control.
Subject: Silica Nanoparticles
Viral Inhibition Mechanism
Editor: Amer Chemical Soc
Citation: Acs Applied Materials & Interfaces. Amer Chemical Soc, v. 8, p. 16564 - 16572, 2016.
Rights: fechado
Identifier DOI: 10.1021/acsami.6b03342
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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