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dc.titleSmoking And Cardiac Structure And Function In The Elderly: The Aric Study (atherosclerosis Risk In Communities)en
dc.contributor.authorJr.; Claggettpt_BR
dc.contributor.authorBrian; Goncalvespt_BR
dc.contributor.authorAlexandra; Querejeta-Rocapt_BR
dc.contributor.authorGabriela; Fernandes-Silvapt_BR
dc.contributor.authorMiguel M.; Shahpt_BR
dc.contributor.authorAmil M.; Chengpt_BR
dc.contributor.authorSusan; Tanakapt_BR
dc.contributor.authorHirofumi; Heisspt_BR
dc.contributor.authorGerardo; Kitzmanpt_BR
dc.contributor.authorDalane W.; Solomonpt_BR
dc.contributor.authorScott D.pt_BR[Nadruz, Wilson, Jr.] Univ Estadual Campinas, Dept Internal Med, Campinas, SP, Brazilpt_BR[Nadruz, Wilson, Jr.pt_BR, Brianpt_BR, Alexandrapt_BR, Gabrielapt_BR, Miguel M.pt_BR, Amil M.pt_BR, Susanpt_BR, Scott D.] Brigham & Womens Hosp, Div Cardiovasc, 75 Francis St, Boston, MA 02115 USApt_BR[Goncalves, Alexandra] Univ Porto, Sch Med, Dept Physiol & Cardiovasc Surg, Rua Campo Alegre 823, P-4100 Oporto, Portugalpt_BR[Tanaka, Hirofumi] Univ Texas Austin, Dept Kinesiol & Hlth Educ, Austin, TX 78712 USApt_BR[Heiss, Gerardo] Univ N Carolina, Dept Epidemiol, Chapel Hill, NC USApt_BR[Kitzman, Dalane W.] Wake Forest Sch Med, Dept Cardiol, Winston Salem, NC USApt_BR
dc.subjectEpidemiological Studiesen
dc.subjectHeart Failureen
dc.description.abstractCigarette smoking has been associated with higher risk of incident heart failure independent of coronary artery disease, but the impact of tobacco use on cardiac structure and function in the general population is uncertain. This study evaluated the relationship between smoking and echocardiographic measures in a large elderly cohort. Methods and Results We studied 4580 participants free of overt coronary artery disease, heart failure, and significant valvular disease from the fifth visit of the ARIC study (Atherosclerosis Risk in Communities) who underwent transthoracic echocardiography. Participants were classified into 3 categories based on self-reported smoking habits: never (43.2%), former (50.5%), and current smokers (6.3%). Pack-years and years of smoking were also estimated. Compared with never smokers, current smokers had greater left ventricular (LV) mass index (80.41.1 versus 76.7 +/- 0.4 g/m(2); P<0.001), LV mass/volume ratio (1.93 +/- 0.03 versus 1.83 +/- 0.03 g/mL; P<0.001), higher prevalence of LV hypertrophy (15% versus 9%; P=0.008), and worse diastolic function, as reflected by higher E/E ratio (11.7 +/- 0.2 versus 10.9 +/- 0.1; P<0.001), after adjusting for potential confounding factors. In contrast, former smokers showed similar echocardiographic features when compared with never smokers. Furthermore, estimated pack-years and years of smoking, measures of cumulative cigarette exposure, were associated with greater LV mass index, LV mass/volume ratio, and worse diastolic function (higher E/E ratio) in current smokers after multivariable analysis (all P<0.01). Conclusions Active smoking and cumulative cigarette exposure were associated with subtle alterations in LV structure and function in an elderly, community-based population free of overt coronary artery disease and heart failure.en
dc.relation.ispartofCirculation-Cardiovascular Imagingpt_BR
dc.publisherLippincott Williams & Wilkinspt_BR
dc.identifier.citationCirculation-cardiovascular Imaging. Lippincott Williams & Wilkins, v. 9, p. , 2016.pt_BR
dc.description.sponsorshipNational Heart, Lung, and Blood Institute (NHLBI) [HHSN268201100005C, HHSN268201100006C, HHSN268201100 007C, HHSN268201100008C, HHSN268201100009C, HHSN 268201100010C, HHSN268201100011C, HHSN268201100 012C]pt_BR
dc.description.sponsorshipNHLBI [NHLBI-HC-11-08, R00-HL-107642, K08-HL-116792]pt_BR
dc.description.sponsorshipEllison Foundationpt_BR
dc.description.sponsorshipPortuguese Foundation for Science and Technology [HMSP-ICS/007/2012]pt_BR
dc.description.sponsorshipBrazilian National Council for Scientific and Technological Development Grant [249481/2013-8]pt_BR
dc.description.provenanceMade available in DSpace on 2017-11-13T13:43:21Z (GMT). No. of bitstreams: 1 000384461800009.pdf: 782930 bytes, checksum: a010dc92819b1d577dd8e2c8b0316088 (MD5) Previous issue date: 2016en
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