Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328522
Type: Artigo
Title: Lysozyme Expression Can Be Useful To Distinguish Mammary Analog Secretory Carcinoma From Acinic Cell Carcinoma Of Salivary Glands
Lysozyme expression can be useful to distinguish mammary analog secretory carcinoma from acinic cell carcinoma of salivary glands
Author: Mariano, Fernanda Viviane
Concha Gomez, Camila Andrea
Nascimento, Juliana de Souza do
Santos, Harim Tavares dos
Egal, Erika Said
Montalli, Victor Angelo Martins
Vargas, Pablo Agustin
Almeida, Oslei Paes de
Altemani, Albina
Abstract: Lysozyme is an enzymatic marker of acinar and intercalated duct cells of normal salivary glands. The aim of this study was to verify whether lysozyme expression could be useful to distinguish acinic cell carcinoma (ACC) from its main mimic, mammary analog secretory carcinoma (MASC). For comparison, DOG1 expression was analyzed as well. Seventeen cases of ACC, 15 MASC, and 125 other salivary tumors were studied. Lysozyme expression was found in tumor cells as well as in secreted material of MASC (86.6 % of cases) and in ductal cells of epithelial-myoepithelial carcinoma (EMC-53.8 %), pleomorphic adenoma (PA-29.1 %) and polymorphous lowgrade adenocarcinoma (PLGA-23.8 %). However, in ACC, lysozyme was not expressed. Three patterns of DOG1 staining were seen: apical-luminal, cytoplasmic, and mixed cytoplasmic/membranous. The apical-luminal pattern was detected in ductal cells of ACC (58.8 % of cases), EMC (38.4 %), adenoid-cystic carcinoma (AdCC-35.3 %), PA (8.3 %), and PLGA (4.8 %). These tumors also showed mixed membranous/cytoplasmic staining for DOG1. MASC, mucoepidermoid, and salivary duct carcinomas exhibited only DOG1 cytoplasmic staining. In conclusion, lysozyme cannot be used as a marker of acinar differentiation in salivary tumors. However, lysozyme expression can be helpful to distinguish MASC from ACC due to its high frequency in the former and absence in ACC. It is likely that in MASC, lysozyme expression may reflect a lactational-like secretory differentiation since lysozyme belongs to breast milk proteins. Regarding DOG1 expression, the apical-luminal pattern is related to acinar and intercalated duct differentiation whereas the cytoplasmic staining does not seem to be associated with a specific cellular phenotype.
Lysozyme is an enzymatic marker of acinar and intercalated duct cells of normal salivary glands. The aim of this study was to verify whether lysozyme expression could be useful to distinguish acinic cell carcinoma (ACC) from its main mimic, mammary analog
Subject: Lysozyme
Dog1
Acinic Cell Carcinoma
Mammary Analog Secretory Carcinoma
Lisozima
Carcinoma de células acinares
Country: Alemanha
Editor: Springer
Citation: Head & Neck Pathology. Springer, v. 10, p. 429 - 436, 2016.
Rights: fechado
Identifier DOI: 10.1007/s12105-016-0718-5
Address: https://link.springer.com/article/10.1007/s12042-016-9166-3
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos
FOP - Artigos e Outros Documentos

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