Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328423
Full metadata record
DC FieldValueLanguage
dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremaildmsouza@unicamp.brpt_BR
dc.typeArtigopt_BR
dc.titleEmploying Proteomics To Unravel The Molecular Effects Of Antipsychotics And Their Role In Schizophreniaen
dc.contributor.authorCassolipt_BR
dc.contributor.authorJuliana S.; Guestpt_BR
dc.contributor.authorPaul C.; Santanapt_BR
dc.contributor.authorAline G.; Martins-de-Souzapt_BR
dc.contributor.authorDanielpt_BR
unicamp.authorMartins-de-Souza, Daniel] Univ Campinas UNICAMP, Inst Biol, Dept Biochem & Tissue Biol, Lab Neuroprote, Campinas, SP, Brazilpt_BR
unicamp.author[Martins-de-Souza, Daniel] Univ Estadual Campinas, Neurobiol Ctr, Campinas, SP, Brazilpt_BR
unicamp.author.external[Cassoli, Juliana S.pt_BR
unicamp.author.externalGuest, Paul C.pt_BR
unicamp.author.externalSantana, Aline G.pt_BR
dc.subjectAntipsychoticsen
dc.subjectProteomicsen
dc.subjectPsychiatric Disordersen
dc.subjectSchizophreniaen
dc.description.abstractSchizophrenia is an incurable neuropsychiatric disorder managed mostly by treatment of the patients with antipsychotics. However, the efficacy of these drugs has remained only low to moderate despite intensive research efforts since the early 1950s when chlorpromazine, the first antipsychotic, was synthesized. In addition, antipsychotic treatment can produce often undesired severe side effects in the patients and addressing these remains a large unmet clinical need. One of the reasons for the low effectiveness of these drugs is the limited knowledge about the molecular mechanisms of schizophrenia, which impairs the development of new and more effective treatments. Recently, proteomic studies of clinical and preclinical samples have identified changes in the levels of specific proteins in response to antipsychotic treatment, which have converged on molecular pathways such as cell communication and signaling, inflammation and cellular growth, and maintenance. The findings of these studies are summarized and discussed in this review and we suggest that this provides validation of proteomics as a useful tool for mining drug mechanisms of action and potentially for pinpointing novel molecular targets that may enable development of more effective medications.en
dc.relation.ispartofProteomics Clinical Applicationspt_BR
dc.publisherWiley-V C H Verlag Gmbhpt_BR
dc.publisherWeinhempt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationabrpt_BR
dc.identifier.citationProteomics Clinical Applications. Wiley-v C H Verlag Gmbh, v. 10, p. 442 - 455, 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume10pt_BR
dc.description.issuenumber4pt_BR
dc.description.firstpage442pt_BR
dc.description.lastpage455pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1862-8346pt_BR
dc.identifier.eissn1862-8354pt_BR
dc.identifier.wosidWOS:000373947200013pt_BR
dc.identifier.doi10.1002/prca.201500109pt_BR
dc.identifier.urlhttp://onlinelibrary.wiley.com/doi/10.1002/prca.201500109/abstractpt_BR
dc.description.sponsorshipFAPESP (Sao Paulo Research Foundation) [2014/14881-1, 2013/08711-3]pt_BR
dc.description.sponsorshipCNPq (The Brazilian National Council for Scientific and Technological Development) [460289/2014-4]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq)pt_BR
dc.date.available2017-11-13T13:25:00Z-
dc.date.accessioned2017-11-13T13:25:00Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:25:00Z (GMT). No. of bitstreams: 1 000373947200013.pdf: 234128 bytes, checksum: 29ae1a9489c81fc7081884e34c682da2 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328423-
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000373947200013.pdf228.64 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.