Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328335
Type: Artigo
Title: Artesunate Ameliorates Experimental Autoimmune Encephalomyelitis By Inhibiting Leukocyte Migration To The Central Nervous System
Artesunate ameliorates experimental autoimmune encephalomyelitis by inhibiting leukocyte migration to the central nervous system
Author: Thomé, Rodolfo
Carvalho, Ana Carolina de
Costa, Thiago Alves da
Ishikawa, Larissa Lumi Watanabe
Fraga-Silva, Thais Fernanda de Campos
Sartori, Alexandrina
Oliveira, Alexandre Leite Rodrigues de
Verinaud, Liana
Abstract: Experimental autoimmune encephalomyelitis (EAE) is T-celldependent disease of the central nervous system (CNS) of mice. This model resembles multiple sclerosis (MS) in many aspects. Therapies that focus in the modulation of the immune response and cellular infiltration in the CNS present best effects in the clinics. Artesunate (Art) is a semi-synthetic sesquiterpene derivative from artemisinin and has been shown to reduce the clinical signs of autoimmune disease models through mechanisms not yet understood. In this study, we aimed to evaluate whether administration of Art would ameliorate EAE. Methods and Results: C57BL6 mice were immunized with MOG(35-55) peptide to induce EAE. At the same time, Art treatment started (3 mg/kg/day via i.p.) for five consecutive days. We found that Art treatment reduced the clinical signs of EAE and that correlated with a reduced infiltration of cells in the CNS. Disease amelioration did not correlate with immunomodulation as recall responses, leukocyte subpopulations, and gene expression analysis were similar among treated and untreated mice. Ultimately, further analysis provided data indicating that a possible mechanism of action for Art is dependent on the cellular migration to the CNS. Conclusions: Artesunate reduces the severity of EAE by inhibiting migration of pathogenic T cells to the CNS.
Experimental autoimmune encephalomyelitis (EAE) is T-celldependent disease of the central nervous system (CNS) of mice. This model resembles multiple sclerosis (MS) in many aspects. Therapies that focus in the modulation of the immune response and cellula
Subject: Artesunato
Movimento celular
Encefalomielite autoimune experimental
Neuroinflamação
Country: Reino Unido
Editor: Wiley
Citation: Cns Neuroscience & Therapeutics. Wiley-blackwell, v. 22, p. 707 - 714, 2016.
Rights: fechado
aberto
Identifier DOI: 10.1111/cns.12561
Address: https://onlinelibrary.wiley.com/doi/full/10.1111/cns.12561
Date Issue: 2016
Appears in Collections:IB - Artigos e Outros Documentos

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