Please use this identifier to cite or link to this item:
Type: Artigo
Title: Hierarchical Structures Of Beta-tcp/45s5 Bioglass Hybrid Scaffolds Prepared By Gelcasting
Author: Lopes
Joao Henrique; Magalhae
Jessica Aparecida; Gouueia
Rubia Figueredo; Bertran
Celso Aparecido; Motisuke
Mariana; Camargo
Samira E. A.; Triches
Eliandra de Sousa
Abstract: This paper investigates the microstructure and the mechanical properties of beta-tricalcium phosphate (beta-TCP) three-dimensional (3D) porous materials reinforced with 45S5 bioactive glass (BG). beta-TCP and beta-TCP/x%-BG scaffolds with interconnected pores networks, suitable for bone regeneration, were fabricated by gel-casting method. Mechanical properties, porosity, and morphological characteristics were evaluated by compressive strength test, scanning electron microscopy (SEM) and X-ray micro tomography analysis, whereas the structures were fully explored by XRD, and Raman spectroscopy. To the best of our knowledge, this is the first time where the mechanism for understanding the effect of bioglass on the mechanical properties and microstruture of beta-TCP/45S5-BG scaffolds has been systematically studied. The findings showed that ionic product lixiviated from 45S5 bioactive glass, rich in silicon species and sodium ion, catalyzes a phase transition from beta-TCP to Si-TCP by replacement of phosphorus for silicon and contributes to the improvement of scaffolds mechanical properties. The compressive strength of beta-TCP/5%-BG and beta-TCP/7.5%-BG was improved around 200% in comparison to pure beta-TCP. Osteoblast-like cells (MG 63) were exposed to the materials for 24 h through the use of medium conditioned by beta-tricalcium phosphate/bioactive glass. Cell viability was measured by MTT assay in the cells and the data obtained were submitted to ANovA, Tukey's multiple comparison (p<0.05). The beta-TCP/7.5-BG promoted an increase of cell proliferation. The results suggest that compositions and processing method studied may provide appropriate materials for tissue engineering. (C) 2016 Elsevier Ltd. All rights reserved.
Subject: Beta-tcp
45s5 Bioglass
Editor: Elsevier Science BV
Citation: Journal Of The Mechanical Behavior Of Biomedical Materials. Elsevier Science Bv, v. 62, p. 10 - 23, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.jmbbm.2016.04.028
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000381238500002.pdf8.39 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.