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Type: Artigo
Title: Alternatives For Reducing Relapse Rate When Switching From Natalizumab To Fingolimod In Multiple Sclerosis
Author: Fragoso
Yara Dadalti; Adoni
Tarso; Alves-Leon
Soniza Vieira; Apostolos-Pereira
Samira Luisa; de Araujo
Yuna Ribeiro; Becker
Jefferson; Bidin Brooks
Joseph Bruno; Correa
Eber Castro; Damasceno
Alfredo; de Albuquerque Damasceno
Carlos Augusto; Ferreira
Maria Lucia B.; da Gama
Paulo Diniz; Diniz da Gama
Rodrigo Assad; Gomes
Sidney; Magno Goncalves
Marcus Vinicius; Grzesiuk
Anderson Kuntz; Nunes Machado
Suzana Costa; da Cunha Matta
Andre Palma; Mendes
Maria Fernanda; Goncalves Jube Ribeiro
Taysa Alexandrino; da Rocha
Cristiane Franklin; Ruocco
Heloisa Helena; Sato
Henry; Simm
Renata Faria; Tauil
Carlos Bernardo; Ferreira Vasconcelos
Claudia Cristina; Ferreira Vieira
Vera Lucia
Abstract: Natalizumab is a therapeutic option for treating multiple sclerosis (MS) and is particularly efficacious for patients with highly active disease. A long washout period has been recommended between withdrawal of natalizumab and start of fingolimod (another option for treating MS). This long washout period has been associated with a significant increase in MS activity. In the present study, a group of 96 patients who were switched from natalizumab to fingolimod had short washout periods between drugs, or monthly corticosteroid pulse therapy if longer washout periods were recommended. This therapeutic approach led to the lowest reported relapse rate so far, among patients with MS switching from natalizumab to fingolimod (8.3%). No complications from short withdrawal were observed in this group of patients.
Subject: Fingolimod
Progressive Multifocal Leukoencephalopathy
Multiple Sclerosis
Editor: Taylor & Francis Ltd
Citation: Expert Review Of Clinical Pharmacology. Taylor & Francis Ltd, v. 9, p. 541 - 546, 2016.
Rights: fechado
Identifier DOI: 10.1586/17512433.2016.1145053
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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