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Type: Artigo
Title: Quality Of Sweat Test (st) Based On The Proportion Of Sweat Sodium (na) And Sweat Chloride (cl) As Diagnostic Parameter Of Cystic Fibrosis: Are We On The Right Way?
Author: Faria
Alethea Guimaraes; Lima Marson
Fernando Augusto; de Souza Gomez
Carla Cristina; Goncalves de Oliveira Ribeiro
Maria Angela; Morais
Lucas Brioschi; Servidoni
Maria de Fatima; Bertuzzo
Carmen Silvia; Sakano
Eulalia; Goto
Maura; Paschoal
Ilma Aparecida; Pereira
Monica Corso; Hessel
Gabriel; Levy
Carlos Emilio; Dalbo Contrera Toro
Adyleia Aparecida; Peixoto
Andressa Oliveira; Ribeiro Simoes
Maria Cristina; Lomazi
Elizete Aparecida; Negrao Nogueira
Roberto Jose; Ribeiro
Antonio Fernando; Ribeiro
Jose Dirceu
Abstract: To assess the quality of sweat test (ST) based on the proportion of sweat sodium and sweat chloride as diagnostic parameter of cystic fibrosis (CF). Methods: A retrospective study of 5,721 sweat samples and subsequent descriptive analysis were carried out. The test was considered "of good quality" (correct) when: (i) sweat chloride was lower than 60 mEq/L, and sweat sodium was higher than sweat chloride; (ii) sweat chloride was higher than 60 mEq/L, and sweat sodium was lower than sweat chloride. Results: The study included 5,692/5,721 sweat samples of ST which had been requested due to clinical presentations compatible with CF and/or neonatal screenings with altered immunoreactive trypsinogen values. Considering the proportion of sweat sodium and sweat chloride as ST quality parameter, the test was performed correctly in 5,023/5,692 (88.2 %) sweat samples. The sweat chloride test results were grouped into four reference ranges for chloride (i) chloride >= 30 mEq/L: 3,651/5,692 (64.1 %); (ii) chloride < 30 mEq/L to < 40 mEq/L: 652/5,692 (11.5 %); (iii) >= 40 mEq/L to < 60 mEq/L: 673/5,692 (11.8 %); (iv) >= 60 mEq/L: 716/5,692 (12.6 %). In the comparative analysis, there was no association between ST quality and: (i) symptoms to indicate a ST [respiratory (p = 0.084), digestive (p = 0.753), nutritional (p = 0.824), and others (p = 0.136)], (ii) sweat weight (p = 0.416). However, there was a positive association with: (i) gender, (ii) results of ST (p < 0.001), (iii) chloride/sodium ratio (p < 0.001), (iv) subject's age at the time of ST [grouped according to category (p < 0.001) and numerical order (p < 0.001)]. For the subset of 169 patients with CF and two CFTR mutations Class I, II and/or III, in comparative analysis, there was a positive association with: (i) sweat chloride/sodium ratio (p < 0.001), (ii) sweat chloride values (p = 0.047), (iii) subject's age at the time of the ST grouped by numerical order (p = 0.001). Conclusions: Considering that the quality of ST can be assessed by levels of sweat sodium and sweat chloride, an increasing number of low-quality tests could be observed in our sweat samples. The quality of the test was associated with important factors, such as gender, CF diagnosis, and subjects' age.
Subject: Cystic Fibrosis
Editor: Biomed Central Ltd
Citation: Diagnostic Pathology. Biomed Central Ltd, v. 11, p. , 2016.
Rights: aberto
Identifier DOI: 10.1186/s13000-016-0555-6
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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