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Type: Artigo
Title: Characterization Of Pcl And Chitosan Nanoparticles As Carriers Of Enoxaparin And Its Antithrombotic Effect In Animal Models Of Venous Thrombosis
Author: Prado
Lucas Bessa; Huber
Stephany Cares; Barnabe
Aline; Santiago Bassora
Fernanda Dutra; Paixao
Devanira Souza; Duran
Nelson; Annichino-Bizzacchi
Joyce Maria
Abstract: This study was based on the preparation, characterization, and animal in vivo experiments performed to evaluate nanoparticles of poly(epsilon-caprolactone) (PCL) and chitosan as carriers of enoxaparin. Thenanoparticles were characterized and presented satisfactory results in terms of size, polydispersity, and encapsulation efficiency. Anticoagulant activity of the nanoparticles was maintained for 14 hours when the administration was subcutaneous; however no activity was observed after oral administration. There was a significant reduction in thrombus size, in vivo, for both free and encapsulated enoxaparin in comparison with the control group after subcutaneous administration. Oral administration results however were indifferent. In conclusion, the double emulsion method w/o/w was efficient for enoxaparin encapsulation, producing spherical nanoparticles with high encapsulation efficiency. For in vivo studies, the encapsulated enoxaparin showed a sustained anticoagulant activity for a higher period of time compared to free enoxaparin, with an antithrombotic effect when administered subcutaneously.
Editor: Hindawi Ltd
Citation: Journal Of Nanotechnology. Hindawi Ltd, p. , 2017.
Rights: aberto
Identifier DOI: 10.1155/2017/4925495
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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