Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328112
Type: Artigo
Title: Pattern Of Reduced Functional Connectivity And Structural Abnormalities In Parkinson's Disease: An Exploratory Study
Author: Guimaraes
Rachel Paes; Arci Santos
Maria Cristina; Dagher
Alain; Campos
Lidiane Soares; Azevedo
Paula; Piovesana
Luiza Gonzaga; De Campos
Brunno Machado; Larcher
Kevin; Zeighami
Yashar; Scarparo Amato-Filho
Augusto C.; Cendes
Fernando; Frota D'Abreu
Anelyssa Cysne
Abstract: MRI brain changes in Parkinson's disease (PD) are controversial. Objectives: We aimed to describe structural and functional changes in PD. Methods: Sixty-six patients with PD (57.94 +/- 10.25 years) diagnosed according to the UK Brain Bank criteria were included. We performed a whole brain analysis using voxel-based morphometry (VBM-SPM 8 software), cortical thickness (CT) using CIVET, and resting-state fMRI using the Neuroimaging Analysis Kit software to compare patients and controls. For VBM and CT we classified subjects into three groups according to disease severity: mild PD [Hoehn and Yahr scale (HY) 1-1.5], moderate PD (HY 2-2.5), and severe PD (HY 3-5). Results: We observed gray matter atrophy in the insula and inferior frontal gyrus in the moderate PD and in the insula, frontal gyrus, putamen, cingulated, and paracingulate gyri in the severe groups. In the CT analysis, in mild PD, cortical thinning was restricted to the superior temporal gyrus, gyrus rectus, and olfactory cortex; in the moderate group, the postcentral gyrus, supplementary motor area, and inferior frontal gyrus were also affected; in the severe PD, areas such as the precentral and postentral gyrus, temporal pole, fusiform, and occipital gyrus had reduced cortical thinning. We observed altered connectivity at the default mode, visual, sensorimotor, and cerebellar networks. Conclusion: Subjects with mild symptoms already have cortical involvement; however, further cerebral involvement seems to follow Braak's proposed mechanism. Similar regions are affected both structurally and functionally. We believe the combination of different MRI techniques may be useful in evaluating progressive brain involvement and they may eventually be used as surrogate markers of disease progression.
Subject: Parkinson's Disease
Neuroimaging
Cortical Thickness
Functional Mri
Voxel-based Morphometry
Editor: Frontiers Media SA
Lausanne
Citation: Frontiers In Neurology. Frontiers Media Sa, v. 7, p. , 2017.
Rights: aberto
Identifier DOI: 10.3389/fneur.2016.00243
Address: http://journal.frontiersin.org/article/10.3389/fneur.2016.00243/full
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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