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dc.titleEffect Of Long-term High-fat Diet Intake On Peripheral Insulin Sensibility, Blood Pressure, And Renal Function In Female Ratsen
dc.contributor.authorNoemi A. V.; Possignolopt_BR
dc.contributor.authorLuiz F.; Palanchpt_BR
dc.contributor.authorAdrianne C.; Gontijopt_BR
dc.contributor.authorJose A. R.pt_BR
unicamp.authorGontijo, Jose A. R.] Univ Estadual Campinas, Fac Ciencias Med, Nucleo Med & Cirurgia Expt, Lab Metab Hidrossalino,Dept Clin Med, Campinas, SP, Brazilpt_BR[Roza, Noemi A. V.pt_BR, Luiz F.pt_BR, Adrianne C.pt_BR
dc.subjectBlood Pressureen
dc.subjectGlucose Tolerance Testen
dc.subjectHigh-fat Dieten
dc.subjectInsulin Sensitivityen
dc.subjectRenal Functionen
dc.description.abstractThis study determines whether 8-week high-fat diet (HFD) consumption alters insulin sensitivity, kidney function, and blood pressure (BP) in female rats when compared with standard rodent diet (ND) intake in gender-and age-matched rats. Methods: The present study investigates, in female Wistar HanUnib rats, the effect of long-term high-fat fed group (HFD) compared with standard chow on BP by an indirect tail-cuff method using an electro-sphygmomanometer, insulin and glucose function, and kidney function by creatinine and lithium clearances. Results: The current study shows glucose tolerance impairment, as demonstrated by increased fasting blood glucose (ND: 78 +/- 2.8 vs. HFD: 87 +/- 3.8 mg/dL) associated with reduced insulin secretion (ND: 0.58 +/- 0.07 vs. HFD: 0.40 +/- 0.03 ng/mL) in 8-week female HFD-treated rats. The incremental area under the curve (AUC, ND: 1,4558.0 +/- 536.0 vs. HFD: 1,6507.8 +/- 661.9), homeostasis model assessment of insulin resistance (HOMA-IR) index, and the first-order rate constant for the disappearance of glucose (Kitt) were significantly enhanced in 8-week HFD-treated rats compared with age-matched ND group (respectively, P = 0.03, P = 0.002, and P<0.0001). The current study also shows a significantly higher systolic BP measured in 5 and 8 weeks posttreatment in HFD (5-week HFD-treated: 155.25 +/- 10.54 mmHg and 8-week HFD-treated: 165 +/- 5.8 mmHg) (P=0.0001), when compared to BP values in 5-week ND, 137 +/- 4.24 mmHg and 8-week ND, 131.75 +/- 5.8 mmHg age-matched group. Otherwise, the glomerular filtration rate and renal sodium handling evaluated by FENa, FEPNa and FEPPNa, were unchanged in both groups. Conclusion: We may conclude that 8-week female HFD-fed rats compared with ND group stimulate harmful effects, such as BP rise and peripheral glucose intolerance. The increased BP occurs through insulin resistance and supposedly decreased vasodilatation response without any change on renal function.en
dc.relation.ispartofFood & Nutrition Researchpt_BR
dc.publisherCo-Action Publishingpt_BR
dc.identifier.citationFood & Nutrition Research. Co-action Publishing, v. 60, p. , 2016.pt_BR
dc.description.sponsorshipFAPESP [2013/12486-5, 2009/513296-0]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.description.sponsorship1Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES)pt_BR
dc.description.provenanceMade available in DSpace on 2017-11-13T13:23:20Z (GMT). No. of bitstreams: 1 000370126600001.pdf: 1253375 bytes, checksum: 08d5553838d1a1c9ec65d34058719f44 (MD5) Previous issue date: 2016en
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