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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremaillinanutricao@gmail.compt_BR
dc.typeArtigopt_BR
dc.titleBioactivity Of Food Peptides: Biological Response Of Rats To Bovine Milk Whey Peptides Following Acute Exerciseen
dc.contributor.authorMourapt_BR
dc.contributor.authorCarolina Soares; Barboza Lollopt_BR
dc.contributor.authorPablo Christiano; Moratopt_BR
dc.contributor.authorPriscila Neder; Rissopt_BR
dc.contributor.authorEder Muller; Amaya-Farfanpt_BR
dc.contributor.authorJaimept_BR
unicamp.authorAmaya-Farfan, Jaime] Univ Estadual Campinas, UNICAMP, Fac Food Engn, Prot Resources Lab,Food & Nutr Dept, Campinas, SP, Brazilpt_BR
unicamp.author.external[Moura, Carolina Soarespt_BR
unicamp.author.externalBarboza Lollo, Pablo Christianopt_BR
unicamp.author.externalMorato, Priscila Nederpt_BR
unicamp.author.externalRisso, Eder Mullerpt_BR
dc.subjectBioactive Peptidesen
dc.subjectWhey Protein Hydrolysateen
dc.subjectHspen
dc.subjectImmuneen
dc.subjectGlycogenen
dc.description.abstractSeveral physiologically beneficial effects of consuming a whey protein hydrolysate (WPH) have been attributed to the greater availability of bioactive peptides. Aims: The aim was to investigate the effect of four branched-chain amino acid-(BCAA) containing dipeptides, present in WPH, on immune modulation, stimulation of HSP expression, muscle protein synthesis, glycogen content, satiety signals and the impact of these peptides on the plasma free amino acid profiles. Methods: The animals were divided in groups: control (rest, without gavage), vehicle (water), Lisoleucyl-L-leucine (lle-Leu), L-leucyl-L-isoleucine (Leu-lle), L-valyl-Lleucine (Val-Leu), L-leucyl-L-valine (Leu-Val) and WPH. All animals were submitted to acute exercise, except for control. Results: lle-Leu stimulated immune response, hepatic and muscle glycogen and HSP60 expression, whereas Leu-Val enhanced HSP90 expression. All dipeptides reduced glucagon-like peptide1 and glucose-dependent insulinotropic polypeptide, no changes were observed on leptin. All peptides inhibited NF-kB expression. The plasma amino acid time-course showed peptide-specific and isomer-specific metabolic features, including increases of the BCAAs. Conclusion: The data indicate that lle-Leu was effective to attenuate immune-suppression exercise-induced, promoted glycogen content and stimulated anti-stress effect (HSP). Furthermore, Leu-Val increased HSP90, p-4EBP1, p-mTOR and p-AMPK expression. The data suggest the involvement of these peptides in various beneficial functions of WPH consumption.en
dc.relation.ispartofFood & Nutrition Researchpt_BR
dc.publisherAbingdonpt_BR
dc.date.issued2017pt_BR
dc.identifier.citationFood & Nutrition Research. , v. 61, p. , 2017.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume61pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1654-6628pt_BR
dc.identifier.eissn1654-661Xpt_BR
dc.identifier.wosidWOS:000396882800001pt_BR
dc.identifier.doi10.1080/16546628.2017.1290740pt_BR
dc.identifier.urlhttp://www.tandfonline.com/doi/full/10.1080/16546628.2017.1290740pt_BR
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP), Brazil [2013/02862-0, 2013/06494-5]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2017-11-13T13:23:19Z-
dc.date.accessioned2017-11-13T13:23:19Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:23:19Z (GMT). No. of bitstreams: 1 000396882800001.pdf: 2578121 bytes, checksum: 70818ba231bea8d070d6b9119d8f02a7 (MD5) Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/328072-
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