Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/328033
Type: Artigo
Title: Natural Killer Cell Assessment In Peripheral Circulation And Bronchoalveolar Lavage Fluid Of Patients With Severe Sepsis: A Case Control Study
Author: Souza-Fonseca-Guimaraes
Paulo; Guimaraes
Fernando; De Souza-Araujo
Caroline Natania; Boldrini Leite
Lidiane Maria; Senegaglia
Alexandra Cristina; Nishiyama
Anita; Souza-Fonseca-Guimaraes
Fernando
Abstract: Sepsis is a complex systemic inflammatory syndrome, the most common cause of which is attributed to systemic underlying bacterial infection. The complete mechanisms of the dynamic pro- and anti-inflammatory processes underlying the pathophysiology of sepsis remain poorly understood. Natural killer (NK) cells play a crucial role in the pathophysiology of sepsis, leading to exaggerated inflammation due their rapid response and production of pro-inflammatory cytokines such as interferon gamma (IFN-gamma). Several studies have already shown that NK cells undergo lymphopenia in the peripheral blood of patients with sepsis. However, our understanding of the mechanisms behind its cellular trafficking and its role in disease development is restricted to studies in animal models. In this study, we aimed to compare the human NK cell subset (CD56(bright or dim)) levels in the peripheral blood and bronchoalveolar lavage (BAL) fluid of sepsis patients. We conducted a case-control study with a sample size consisting of 10 control patients and 23 sepsis patients enrolled at the Hospital Cajuru (Curitiba/PR, Brazil) from 2013 to 2015. Although we were able to confirm previous observations of peripheral blood lymphopenia, no significant differences were detected in NK cell levels in the BAL fluid of these patients. Overall, these findings strengthened the evidence that peripheral blood lymphopenia is likely to be associated with cell death as a consequence of sepsis.
Subject: Natural Killer (nk) Cells
Lung Sepsis
Lymphopenia
Bronchoalveolar Lavage (bal)
Editor: MDPI AG
Basel
Rights: aberto
Identifier DOI: 10.3390/ijms18030616
Address: http://www.mdpi.com/1422-0067/18/3/616
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000396253700147.pdf743.42 kBAdobe PDFView/Open


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.