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Type: Artigo
Title: Anti-ro/ssa And Anti-la/ssb Antibodies: Association With Mild Lupus Manifestations In 645 Childhood-onset Systemic Lupus Erythematosus
Author: Novak
Glaucia V.; Marques
Mariana; Balbi
Verena; Gormezano
Natali W. S.; Kozu
Katia; Sakamoto
Ana P.; Pereira
Rosa M. R.; Terreri
Maria T.; Magalhaes
Claudia S.; Guariento
Andressa; Sallum
Adriana M. E.; Marini
Roberto; Leme Ferriani
Virginia Paes; Barbosa
Cassia Maria; Monteiro de Castro
Tania Caroline; Ramos
Valeria C.; Bonfa
Eloisa; Silva
Clovis A.
Abstract: To our knowledge there are no studies assessing anti-Ro/SSA and anti-La/SSB autoantibodies in a large population of childhood-systemic lupus erythematosus (cSLE) patients. Methods: This was a retrospective multicenter cohort study performed in 10 Pediatric Rheumatology services, Sao Paulo state, Brazil. Anti-Ro/SSA and anti-La/SSB antibodies were measured by enzyme linked immunosorbent assay (ELISA) in 645 cSLE patients. Results: Anti-Ro/SSA and anti-La/SSB antibodies were evidenced in 209/645 (32%) and 102/645 (16%) of cSLE patients, respectively. Analysis of cSLE patients with and without anti-Ro/SSA antibodies revealed higher frequencies of malar rash (79% vs. 71%, p = 0.032), photosensitivity (73% vs. 65%, p = 0.035), cutaneous vasculitis (43% vs. 35%, p = 0.046) and musculoskeletal involvement (82% vs. 75%, p = 0.046) in spite of long and comparable disease duration in both groups (4.25 vs. 4.58 years, p = 0.973). Secondary Sjogren syndrome was observed in only five patients with this antibody (2.5% vs. 0%, p = 0.0035), two of them with concomitant anti-La/SSB. The presence of associated autoantibodies: anti-Sm (50% vs. 30%, p < 0.0001), anti-RNP (39% vs. 21%, p < 0.0001) and anti-ribossomal P protein (46% vs. 21%, p = 0.002) was also significantly higher in patients with anti-Ro/SAA antibodies. Further evaluation of cSLE patients with the presence of anti-La/SSB antibodies compared to those without these autoantibodies showed that the frequency of alopecia (70% vs. 51%, p = 0.0005), anti-Sm (59% vs. 31%, p < 0.0001) and anti-RNP (42% vs. 23%, p < 0.0001) were significantly higher in the former group. Conclusions: Our large multicenter cohort study provided novel evidence in cSLE that anti-Ro/SSA and/or anti-La/SSB antibodies were associated with mild manifestations, particularly cutaneous and musculoskeletal. Secondary Sjogren syndrome was rarely observed in these patients, in spite of comparable frequencies of anti-Ro/SSA and/or anti-La/SSB reported for adult SLE. (C) 2016 Elsevier B.V. All rights reserved.
Subject: Anti-ro/ssa Autoantibodies
Anti-la/ssb Autoantibodies
Sjogren Syndrome And Childhood-systemic
Lupus Erythematosus
Multicenter Cohort
Editor: Elsevier Science BV
Citation: Autoimmunity Reviews. Elsevier Science Bv, v. 16, p. 132 - 135, 2017.
Rights: fechado
Identifier DOI: 10.1016/j.autrev.2016.12.004
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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