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Type: Artigo
Title: The Brazilian Amaryllidaceae As A Source Of Acetylcholinesterase Inhibitory Alkaloids
Author: Paulo de Andrade
Jean; Giordani
Raquel B.; Torras-Claveria
Laura; Belen Pigni
Natalia; Berkov
Strahil; Font-Bardia
Merce; Calvet
Teresa; Konrath
Eduardo; Bueno
Kelly; Sachett
Liana G.; Dutilh
Julie H.; Borges
Warley de Souza; Viladomat
Francesc; Henriques
Amelia T.; Nair
Jerald J.; Zuanazzi
Jose Angelo S.; Bastida
Abstract: Nine Brazilian Amaryllidaceae species were studied for their alkaloid composition and acetylcholinesterase (AChE) inhibitory activity via GC-MS and a modified Ellman assay, respectively. A total of thirty-six alkaloids were identified in these plants, of which Hippeastrum papilio and H. glaucescens exhibited the highest galanthamine content and the best IC50 values against AChE. Furthermore, Hippeastrum vittatum and Rhodophiala bifida also showed notable AChE inhibitory effects. X-ray crystallographic data for four galanthamine-type compounds revealed significant differences in the orientation of the N-methyl group, which are shown to be related to AChE inhibition.
Subject: Galanthamine
X-ray Crystallography
Editor: Springer
Citation: Phytochemistry Reviews. Springer, v. 15, p. 147 - 160, 2016.
Rights: fechado
Identifier DOI: 10.1007/s11101-015-9411-7
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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