Please use this identifier to cite or link to this item:
Type: Artigo
Title: Aqueous Leaf Extract Of Passiflora Alata Curtis Promotes Antioxidant And Anti-inflammatory Effects And Consequently Preservation Of Nod Mice Beta Cells (non-obese Diabetic)
Aqueous leaf extract of passiflora alata curtis promotes antioxidant and anti-inflammatory effects and consequently preservation of NOD mice beta cells (non-obese diabetic)
Author: De Figueiredo, Daniella
Colomeu, Talita Cristina
Schumacher, Nayara Simon Gonzalez
Stivanin-Silva, L.G.
Cazarin, Cinthia Baú Betim
Meletti, Laura Maria Molina
Fernandes, Luis Gustavo Romani
Prado, Marcelo Alexandre
Zollner, Ricardo de Lima
Abstract: Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties; the present study aimed to investigate the anti-diabetogenic properties of P. alata aqueous leaf extract. HPLC analysis identified the phenolic compounds catechin, epicatechin and rutin. The aqueous extract was administered for 30 weeks to non-obese diabetic (NOD) mice presenting a decrease of 28.6% in diabetes incidence and the number of inflammatory cells in pancreatic islets, when compared with the control group (water). The P. alata group presented an antioxidant effect and decreased lipid peroxidation in the serum of NOD mice. Increased numbers of insulin-positive cells were also observed in the pancreatic islets of the treated group. The diabetic group exhibited higher levels in the glucose tolerance test and glycemic index, in comparison to the P. alata-treated group and non-diabetic control BALB/c mice. In addition, the P. alata extract reduced the percentage and the proliferation index of NOD mice lymphocytes submitted to in vitro dose/response mitogenic stimulation assays. These results suggest that the aqueous extract of P. alata has anti-inflammatory properties, contributing to the protection of beta cells in pancreatic islets in NOD mice, and presents potential for use a supporting approach to treat type I diabetes. (C) 2016 Elsevier B.V. All rights reserved.
Passiflora alata Curtis (P. alata) leaves have anti-inflammatory properties, the present study aimed to investigatethe anti-diabetogenic properties of P. alata aqueous leaf extract.HPLC analysis identified the phenolic compoundscatechin, epicatechin a
Subject: Anti-inflammatory Effect
Passiflora Elate Curtis
Type 1 Diabetes Mellitus
Nod Mice
Diabetes mellitus tipo 1
Camundongos endogâmicos NOD
Country: Reino Unido
Editor: Elsevier
Citation: International Immunopharmacology. Elsevier Science Bv, v. 35, p. 127 - 136, 2016.
Rights: fechado
Identifier DOI: 10.1016/j.intimp.2016.03.031
Date Issue: 2016
Appears in Collections:FCM - Artigos e Outros Documentos
FEA - Artigos e Outros Documentos

Files in This Item:
File SizeFormat 
000376212500015.pdf1.8 MBAdobe PDFView/Open

Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.