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Type: Artigo
Title: Steroid Hormone Receptors As Potential Mediators Of The Clinical Effects Of Dutasteride: A Prospective, Randomized, Double-blind Study
Author: Alonso
Joao C. C.; Reis
Leonardo O.; Garcia
Patrick V.; Ferreira
Ubirajara; Matheus
Wagner E.; Simoes
Fabiano A.; Rejowski
Ronald F.; Alonso-Vale
Maria Isabel C.; Favaro
Wagner J.
Abstract: This study characterizes the clinical and morphofunctional effects of a 5 alpha-reductase inhibitor on steroid hormone receptors in normal human prostate tissue, as potential mediators of the clinical effects of dutasteride. This work was a prospective, double-blind, and randomized study that evaluated 49 men aged between 45 and 70 years, with no alterations in a digital rectal examination and prostate-specific antigen measurements between 2.5 and 4.0 ng/mL. These patients underwent prostate biopsy guided by transretal ultrasound with prostate neoplasia being ruled out, and the patients were divided into two groups, with one group receiving dutasteride (n = 25) and one group receiving a placebo (n = 24). The patients were clinically assessed each quarter, and at the end of 12 months they underwent new laboratory tests, prostate rebiopsy, and histopathological, immunohistochemical and clinical analyses. The estrogen receptor-beta (ER beta) and androgen receptor immunoreactivities were higher, and the proliferation/apoptotic ratio was significantly lower with predominance of the apoptotic process, followed by a significant reduction in the prostate volume and the total serum prostate-specific antigen levels in the dutasteride group when compared with the placebo group, with a clear supremacy of ER beta. There were no significant variations in the serum estrogen and testosterone levels, in the body mass index, or in the ER alpha immunoreactivities in the dutasteride and placebo groups. The results demonstrated the importance of the ER beta pathway in the activation mechanisms of apoptosis, exerting a protective effect in the normal prostate, indicating that this receptor might be an important mediator of the clinical effects of dutasteride.
Subject: Prostate
Steroid Sex Hormones
Androgen Receptor
Estrogen Receptor
5 Alpha-reductase Inhibitors
Editor: Sage Publications Inc
Thousand Oaks
Citation: American Journal Of Mens Health. Sage Publications Inc, v. 11, p. 126 - 133, 2017.
Rights: fechado
Identifier DOI: 10.1177/1557988315602961
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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