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Type: Artigo
Title: The Phenotypic Spectrum Of Congenital Zika Syndrome
Author: del Campo
Miguel; Feitosa
Ian M. L.; Ribeiro
Erlane M.; Horovitz
Dafne D. G.; Pessoa
Andre L. S.; Franca
Giovanny V. A.; Garcia-Alix
Alfredo; Doriqui
Maria J. R.; Wanderley
Hector Y. C.; Sanseverino
Maria V. T.; Neri
Joao I. C. F.; Pina-Neto
Joao M.; Santos
Emerson S.; Vercosa
Islane; Cernach
Mirlene C. S. P.; Medeiros
Paula F. V.; Kerbage
Saile C.; Silva
Andre A.; van der Linden
Vanessa; Martelli
Celina M. T.; Cordeiro
Marli T.; Dhalia
Rafael; Vianna
Fernanda S. L.; Victora
Cesar G.; Cavalcanti
Denise P.; Schuler-Faccini
Abstract: In October 2015, Zika virus (ZIKV) outbreak the Brazilian Ministry of Health (MoH). In response, the Brazilian Society of Medical Genetics established a task force (SBGM-ZETF) to study the phenotype of infants born with microcephaly due to ZIKV congenital infection and delineate the phenotypic spectrum of this newly recognized teratogen. This study was based on the clinical evaluation and neuroimaging of 83 infants born during the period from July, 2015 to March, 2016 and registered by the SBGM-ZETF. All 83 infants had significant findings on neuroimaging consistent with ZIKV congenital infection and 12 had confirmed ZIKV IgM in CSF. A recognizable phenotype of microcephaly, anomalies of the shape of skull and redundancy of the scalp consistent with the Fetal Brain Disruption Sequence (FBDS) was present in 70% of infants, but was most often subtle. In addition, features consistent with fetal immobility, ranging from dimples (30.1%), distal hand/finger contractures (20.5%), and feet malpositions (15.7%), to generalized arthrogryposis (9.6%), were present in these infants. Some cases had milder microcephaly or even a normal head circumference (HC), and other less distinctive findings. The detailed observation of the dysmorphic and neurologic features in these infants provides insight into the mechanisms and timings of the brain disruption and the sequence of developmental anomalies that may occur after prenatal infection by the ZIKV.
Subject: Congenital Zika Infection
Congenital Zika Sequence
Congenital Zika Syndrome
Disruptive Sequence
Fetal Brain Disruption Sequence
Zika Virus
Editor: Wiley-Blackwell
Rights: fechado
Identifier DOI: 10.1002/ajmg.a.38170
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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