Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327933
Type: Artigo
Title: Antibacterial Silk Fibroin/nanohydroxyapatite Hydrogels With Silver And Gold Nanoparticles For Bone Regeneration
Author: Ribeiro
Marta; Ferraz
Maria P.; Monteiro
Fernando J.; Fernandes
Maria H.; Beppu
Marisa M.; Mantione
Daniele; Sardon
Haritz
Abstract: The rapid emergence of antibiotic resistance is becoming an imminent problem in bone tissue engineering, and therefore biomaterials must be modified to promote the tissue integration before bacterial adhesion. In this work, silk fibroin/nanohydroxyapatite hydrogel was modified with in situ synthesized silver and gold nanoparticles (AgNPs and AuNPs), taking advantage of the tyrosine amino acid. The presence of AgNPs and AuNPs in the hydrogels was characterized by UV spectrophotometer, transmission electron microscopy and thermogravimetric analysis. In vitro antimicrobial studies revealed that hydrogels with AgNPs and AuNPs exhibited significant inhibition ability against both gram-positive and gram-negative bacteria. Cytocompatibility studies carried out using osteoblastic cells revealed that up to 0.5 wt% of AgNPs, and for all concentrations of AuNPs, the hydrogels can be effectively used as antimicrobial materials, without compromising cell behavior. On the basis of the aforementioned observations, these hydrogels are very attractive for bone tissue engineering. (C) 2016 Elsevier Inc. All rights reserved.
Subject: Silk Fibroin
Nanohydroxyapatite
Silver Nanoparticles
Gold Nanoparticles
Antimicrobial Activity
Editor: Elsevier Science BV
Amsterdam
Citation: Nanomedicine-nanotechnology Biology And Medicine. Elsevier Science Bv, v. 13, p. 231 - 239, 2017.
Rights: fechado
Identifier DOI: 10.1016/j.nano.2016.08.26
Address: http://www.sciencedirect.com/science/article/pii/S1549963416301423?via%3Dihub
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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