Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327904
Type: Book
Title: Tor Signaling And Nutrient Sensing
Author: Dobrenel
Thomas; Caldana
Camila; Hanson
Johannes; Robaglia
Christophe; Vincentz
Michel; Veit
Bruce; Meyer
Christian
Abstract: All living organisms rely on nutrients to sustain Cell Metabolism and energy production, which in turn need to be adjusted based on available resources. The evolutionarily conserved target of rapamycin (TOR) protein kinase is a central regulatory hub that connects environmental information about the quantity and quality of nutrients to developmental and metabolic processes in order to maintain cellular homeostasis. TOR is activated by both nitrogen and carbon metabolites and promotes energy-consuming processes such as cell division, mRNA translation, and anabolism in times of abundance while repressing nutrient remobilization through autophagy. In animals and yeasts, TOR acts antagonistically to the starvation-induced AMP-activated kinase (AMPK)/sucrose nonfermenting 1 (Snf1) kinase, called Snf1-related kinase 1 (SnRK1) in plants. This review summarizes the immense knowledge on the relationship betweenTORsignaling and nutrients in nonphotosynthetic organisms and presents recent findings in plants that illuminate the crucial role of this pathway in conveying nutrient-derived signals and regulating many aspects of metabolism and growth.
Subject: Tor Kinase
Snrk1 Kinase
Nutrient Signaling
Sugars
Nitrogen
Editor: Annual Reviews
Palo Alto
Rights: fechado
Identifier DOI: 10.1146/annurev-arplant-043014-114648
Address: http://www.annualreviews.org/doi/full/10.1146/annurev-arplant-043014-114648?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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