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Type: Artigo
Title: L-asparaginase Purification
Author: Tundisi
Louise L.; Coelho
Diego F.; Zanchetta
Beatriz; Moriel
Patricia; Pessoa
Jr.; Tambourgi
Elias B.; Silveira
Edgar; Mazzola
Priscila G.
Abstract: L-asparaginase (L-ASNase) is the gold standard enzyme used to treat acute lymphoblastic leukemia. This disease primarily affects children; however, treatment increases survival from 20% to 90%. As a bioproduct, it is obtained via a biotechnological process and its purification usually consists of several steps that account for up to 80% of the total production costs. This review discusses available strategies for the purification of L-ASNase and highlights a process with fewer steps, and consequently, lower cost and higher yield. This process emphasizes the possibility of using a novel aqueous two-phase system extraction process to purify L-ASNase.
Subject: Aqueous-two Phase System
Downstream Process
Editor: Taylor & Francis Inc
Citation: Separation And Purification Reviews. Taylor & Francis Inc, v. 46, p. 35 - 43, 2016.
Rights: fechado
Identifier DOI: 10.1080/15422119.2016.1184167
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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