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Louise L.; Coelho
Diego F.; Zanchetta
Elias B.; Silveira
|Abstract:||L-asparaginase (L-ASNase) is the gold standard enzyme used to treat acute lymphoblastic leukemia. This disease primarily affects children; however, treatment increases survival from 20% to 90%. As a bioproduct, it is obtained via a biotechnological process and its purification usually consists of several steps that account for up to 80% of the total production costs. This review discusses available strategies for the purification of L-ASNase and highlights a process with fewer steps, and consequently, lower cost and higher yield. This process emphasizes the possibility of using a novel aqueous two-phase system extraction process to purify L-ASNase.|
|Subject:||Aqueous-two Phase System|
|Editor:||Taylor & Francis Inc|
|Citation:||Separation And Purification Reviews. Taylor & Francis Inc, v. 46, p. 35 - 43, 2016.|
|Appears in Collections:||Unicamp - Artigos e Outros Documentos|
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