Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327838
Type: Artigo
Title: Pubertal Exposure To Ethinylestradiol Promotes Different Effects On The Morphology Of The Prostate Of The Male And Female Gerbil During Aging
Author: Perez
Ana P. S.; Biancardi
Manoel F.; Caires
Cassia R. S.; Falleiros
Luiz R.
Jr.; Goes
Rejane M.; Santos
Fernanda C. A.; Taboga
Sebastiao R.
Abstract: In rodents, the final growth and maturation of the prostate occur at puberty, a crucial period for prostate development. The present study is a serological, morphological, morphometric, and immunohistochemical analysis of the effects of exposure to ethinylestradiol (EE) (15 mu g/kg/day) during puberty (EE/PUB group) on the male ventral and female prostate in senile gerbils. In the study, male and female gerbils (Meriones unguiculatus) (42 days) received by gavage 15 g/kg/day of EE (a component of the contraceptive pill), diluted in 100 mu L of Nujol (R) for 1 week (EE/PUB group). In the control group, males and females were not treated. Animals were killed (n = 5) after 12 months in the experimental groups. In the senile male in the EE/PUB group, we observed a reduction in testosterone levels and a decrease in the prostatic epithelial thickness, as well as in the thickness of the muscle layer. In addition, an increase in PIN multiplicity and prostatic inflammation was observed. In the senile female in the EE/PUB group, we observed increased testosterone and estradiol levels, an enhanced prostatic epithelial thickness and an increase in the thickness of the muscle layer. Immunohistochemical analysis revealed an increase in positive cells (%) for AR and PCNA in the male prostate and an increase in positive basal cells for p63 in the female prostate of the EE/PUB group. Exposure to EE during puberty resulted in an inhibitory action on the male ventral prostate and an anabolic effect on the female prostate in senile gerbils. (c) 2016 Wiley Periodicals, Inc. Environ Toxicol 32: 477-489, 2017.
Subject: Ethinylestradiol
Male
Female
Prostate
Puberty
Senescence
Editor: Wiley-Blackwell
Hoboken
Citation: Environmental Toxicology. Wiley-blackwell, v. 32, p. 477 - 489, 2017.
Rights: fechado
Identifier DOI: 10.1002/tox.22252
Address: http://onlinelibrary.wiley.com/doi/10.1002/tox.22252/abstract;jsessionid=2F8CBE75087D0FD31C819D1D4DA0198E.f02t01
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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