Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327800
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailpessoajr@usp.brpt_BR
dc.typeArtigopt_BR
dc.titleBiopharmaceuticals From Microorganisms: From Production To Purificationen
dc.contributor.authorJozalapt_BR
dc.contributor.authorAngela Faustino; Geraldespt_BR
dc.contributor.authorDanilo Costa; Tundisipt_BR
dc.contributor.authorLouise Lacalendola; Feitosapt_BR
dc.contributor.authorValker de Araujo; Breyerpt_BR
dc.contributor.authorCarlos Alexandre; Cardosopt_BR
dc.contributor.authorSamuel Leite; Mazzolapt_BR
dc.contributor.authorPriscila Gava; de Oliveira-Nascimentopt_BR
dc.contributor.authorLaura; Rangel-Yaguipt_BR
dc.contributor.authorCarlota de Oliveira; Magalhaespt_BR
dc.contributor.authorPerola de Oliveira; de Oliveirapt_BR
dc.contributor.authorMarcos Antonio; Pessoapt_BR
dc.contributor.authorAdalbertopt_BR
dc.contributor.authorJr.pt_BR
unicamp.authorTundisi, Louise Lacalendola] Univ Campinas UNICAMP, Inst Biol, Programa Posgrad Biociencias & Tecnol Prod Bioati, Campinas, SP, Brazilpt_BR
unicamp.authorde Oliveira-Nascimento, Laura] Univ Estadual Campinas, Fac Ciencias Farmaceut, Campinas, SP, Brazilpt_BR
unicamp.author[de Oliveira-Nascimento, Laura] Univ Estadual Campinas, Inst Biol, Dept Bioquim & Biol Tecidual, Campinas, SP, Brazilpt_BR
unicamp.author.external[Jozala, Angela Faustino] Univ Sorocaba UNISO, Dept Tecnol & Proc Ambiental, Sorocaba, SP, Brazilpt_BR
unicamp.author.external[Geraldes, Danilo Costapt_BR
unicamp.author.external[Feitosa, Valker de Araujopt_BR
unicamp.author.externalRangel-Yagui, Carlota de Oliveirapt_BR
unicamp.author.externalPessoa, Adalberto, Jr.] Univ Sao Paulo, Dept Bioquim & Tecnol Farmaceut, Sao Paulo, SP, Brazilpt_BR
unicamp.author.external[Breyer, Carlos Alexandrept_BR
unicamp.author.externalde Oliveira, Marcos Antonio] Univ Estadual Sao Paulo UNESP, Inst Biociencias, Campus Litoral Paulista, Sao Paulo, SP, Brazilpt_BR
unicamp.author.external[Cardoso, Samuel Leite] Univ Brasilia, Fac Ciencias Saude, Programa Posgrad Ciencias Farmaceut, Brasilia, DF, Brazilpt_BR
unicamp.author.external[Mazzola, Priscila Gavapt_BR
unicamp.author.external[Magalhaes, Perola de Oliveira] Univ Brasilia, Fac Ciencias Saude, Dept Farm, Brasilia, DF, Brazilpt_BR
dc.subjectBiopharmaceuticalsen
dc.subjectFermentation Processen
dc.subjectBiotechnologyen
dc.subjectUpstream Processen
dc.subjectDownstream Processen
dc.description.abstractThe use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN alpha, beta, and gamma) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals. (C) 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda.en
dc.relation.ispartofBrazilian Journal of Microbiologypt_BR
dc.publisherSoc Brasileira Microbiologiapt_BR
dc.publisherSão Paulopt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationdezpt_BR
dc.identifier.citationBrazilian Journal Of Microbiology. Soc Brasileira Microbiologia, v. 47, p. 51 - 63, 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume47pt_BR
dc.description.issuesupplement1pt_BR
dc.description.firstpage51pt_BR
dc.description.lastpage63pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1517-8382pt_BR
dc.identifier.eissn1678-4405pt_BR
dc.identifier.wosidWOS:000394047600005pt_BR
dc.identifier.doi10.1016/j.bjm.2016.10.007pt_BR
dc.identifier.urlhttp://www-sciencedirect-com.ez88.periodicos.capes.gov.br/science/article/pii/S1517838216310413?via%3Dihubpt_BR
dc.date.available2017-11-13T13:21:59Z-
dc.date.accessioned2017-11-13T13:21:59Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:21:59Z (GMT). No. of bitstreams: 1 000394047600005.pdf: 1981439 bytes, checksum: 35f463a492bb26d3c708478fdc522345 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327800-
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