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Type: Artigo
Title: Biopharmaceuticals From Microorganisms: From Production To Purification
Author: Jozala
Angela Faustino; Geraldes
Danilo Costa; Tundisi
Louise Lacalendola; Feitosa
Valker de Araujo; Breyer
Carlos Alexandre; Cardoso
Samuel Leite; Mazzola
Priscila Gava; de Oliveira-Nascimento
Laura; Rangel-Yagui
Carlota de Oliveira; Magalhaes
Perola de Oliveira; de Oliveira
Marcos Antonio; Pessoa
Abstract: The use of biopharmaceuticals dates from the 19th century and within 5-10 years, up to 50% of all drugs in development will be biopharmaceuticals. In the 1980s, the biopharmaceutical industry experienced a significant growth in the production and approval of recombinant proteins such as interferons (IFN alpha, beta, and gamma) and growth hormones. The production of biopharmaceuticals, known as bioprocess, involves a wide range of techniques. In this review, we discuss the technology involved in the bioprocess and describe the available strategies and main advances in microbial fermentation and purification process to obtain biopharmaceuticals. (C) 2016 Sociedade Brasileira de Microbiologia. Published by Elsevier Editora Ltda.
Subject: Biopharmaceuticals
Fermentation Process
Upstream Process
Downstream Process
Editor: Soc Brasileira Microbiologia
São Paulo
Citation: Brazilian Journal Of Microbiology. Soc Brasileira Microbiologia, v. 47, p. 51 - 63, 2016.
Rights: aberto
Identifier DOI: 10.1016/j.bjm.2016.10.007
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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