Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327775
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailmotta.adrianam@gmail.compt_BR
dc.typeArtigopt_BR
dc.titleBiological Evaluation Of Pldla Polymer Synthesized As Construct On Bone Tissue Engineering Applicationen
dc.contributor.authorMaspt_BR
dc.contributor.authorBruna Antunes; de Luna Freirept_BR
dc.contributor.authorDiego Coutinho; de Melo Cattanipt_BR
dc.contributor.authorSilvia Mara; Mottapt_BR
dc.contributor.authorAdriana Cristina; Peris Barbopt_BR
dc.contributor.authorMaria Lourdes; de Rezende Duekpt_BR
dc.contributor.authorEliana Aparecidapt_BR
unicamp.authorde Rezende Duek, Eliana Aparecida] State Univ Campinas UNICAMP, Rua Mendeleyev 200, BR-13083970 Campinas, SP, Brazilpt_BR
unicamp.author.external[Mas, Bruna Antunespt_BR
unicamp.author.external[de Luna Freire, Diego Coutinhopt_BR
unicamp.author.externalde Melo Cattani, Silvia Marapt_BR
unicamp.author.externalMotta, Adriana Cristinapt_BR
unicamp.author.externalPeris Barbo, Maria Lourdespt_BR
unicamp.author.externalde Rezende Duek, Eliana Aparecida] PUC SP, Rua Joubert Wey 290, BR-18030070 Sorocaba, SP, Brazilpt_BR
dc.subjectBone Tissue Engineeringen
dc.subjectConstructsen
dc.subjectImplantsen
dc.subjectOsteoblast-like Cellsen
dc.subjectPldlaen
dc.description.abstractIn bone tissue engineering, cell-scaffold constructs are used to stimulate complete, functional tissue replacement that does not occur naturally in critical-size defects. In this report, we describe the application potential of poly (L-co-D,L lactic acid)-PLDLA 70/30, synthesized in house as constructs loaded with osteoblast-like cells on bone tissue engineering. In vitro biological results show that the porogen leached PLDLA scaffolds are cytocompatible with osteoblast cells, able to stimulate significant cells growth during the first 14 days of culture, during which the morphology and cell behavior of osteoblasts cultured on the scaffolds were monitored by scanning electron microscopy (SEM). In vivo, PLDLA constructs were implanted in 5 mm bilateral critical-size defects created in rat-calvariae and then evaluated histologically 8 and 12 weeks after implantation. The histological results showed that PLDLA constructs supported the growth of new tissue, with a degradation rate close to that of native bone formation and decrease of inflammatory response over time of implantation. These data provide evidences that the synthesized PLDLA polymer has application potential as construct for bone tissue engineering.en
dc.relation.ispartofMaterials Research-Ibero-American Journal of Materialspt_BR
dc.publisherUniversidade Federal de Sao Carlos, Dept Engenharia Materialspt_BR
dc.publisherSão Carlospt_BR
dc.date.issued2016pt_BR
dc.date.monthofcirculationmar-abrpt_BR
dc.identifier.citationMaterials Research-ibero-american Journal Of Materials. Universidade Federal De Sao Carlos, Dept Engenharia Materials, v. 19, p. 300 - 307, 2016.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume19pt_BR
dc.description.issuenumber2pt_BR
dc.description.firstpage300pt_BR
dc.description.lastpage307pt_BR
dc.rightsabertopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1516-1439pt_BR
dc.identifier.eissn1980-5373pt_BR
dc.identifier.wosidWOS:000374233300005pt_BR
dc.identifier.doi10.1590/1980-5373-MR-2015-0559pt_BR
dc.identifier.urlhttp://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-14392016000200300&lng=en&tlng=enpt_BR
dc.description.sponsorshipFundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2012/12081-2]pt_BR
dc.description.sponsorshipNational Institute of Science and Technology in Biofabrication (INCT-Biofabris)pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2017-11-13T13:21:34Z-
dc.date.accessioned2017-11-13T13:21:34Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:21:34Z (GMT). No. of bitstreams: 1 000374233300005.pdf: 2450908 bytes, checksum: e46d135891d44130b1b341d051a26363 (MD5) Previous issue date: 2016en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327775-
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