Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327767
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dc.contributor.CRUESPUNIVERSIDADE DE ESTADUAL DE CAMPINASpt_BR
dc.contributor.authoremailcarmenl@fcm.unicamp.brpt_BR
dc.typeArtigopt_BR
dc.titleVegf Gene Polymorphisms And Outcome Of Epithelial Ovarian Cancer Patientsen
dc.contributor.authorCamerinpt_BR
dc.contributor.authorGabriela Ribeiro; Carvalho Britopt_BR
dc.contributor.authorAngelo Borsarelli; Vassallopt_BR
dc.contributor.authorJose; Mauricette Derchainpt_BR
dc.contributor.authorSophie Francoise; Passos Limapt_BR
dc.contributor.authorCarmen Silviapt_BR
unicamp.author[Camerin, Gabriela Ribeiro] Pontifical Catholic Univ Campinas, Fac Med, Campinas, SP, Brazilpt_BR
unicamp.authorPassos Lima, Carmen Silvia] Univ Estadual Campinas, Dept Internal Med, Fac Med Sci, Campinas, SP, Brazilpt_BR
unicamp.author[Vassallo, Jose] Univ Estadual Campinas, Lab Mol & Investigat Pathol, Fac Med Sci, Campinas, SP, Brazilpt_BR
unicamp.author[Mauricette Derchain, Sophie Francoise] Univ Estadual Campinas, Dept Obstet & Gynecol, Fac Med Sci, Campinas, SP, Brazilpt_BR
unicamp.author.external[Carvalho Brito, Angelo Borsarellipt_BR
dc.subjectEpithelial Ovarian Canceren
dc.subjectGenetic Polymorphismen
dc.subjectPrognosisen
dc.subjectVegfen
dc.description.abstractSince VEGF polymorphisms were associated with variable protein production, we analyzed herein their roles in outcome of epithelial ovarian cancer (EOC) patients. Methods: Genotypes of 85 patients with primary EOC were identified in DNA by real-time PCR. Progression-free survival and overall survival were analyzed using Kaplan-Meier method, univariate Cox model and bootstrap resampling study. Results: At 60 months of follow-up, progression-free survival was shorter in patients with VEGF c.-2578 CC genotype compared with others (52.7 vs 82.2%; p = 0.04). Those patients had 2.15 more chance of presenting disease progression than others (p = 0.04); bootstrap study validated the result (p = 0.03). Conclusion: Our data suggest that VEGF c.-2578C>A polymorphism acts as a prognostic factor in EOC.en
dc.relation.ispartofFuture Oncologypt_BR
dc.publisherFuture Medicine LTDpt_BR
dc.publisherLondonpt_BR
dc.date.issued2017pt_BR
dc.date.monthofcirculationfevpt_BR
dc.identifier.citationFuture Oncology. Future Medicine Ltd, v. 13, p. 409 - 414, 2017.pt_BR
dc.language.isoEnglishpt_BR
dc.description.volume13pt_BR
dc.description.issuenumber5pt_BR
dc.description.firstpage409pt_BR
dc.description.lastpage414pt_BR
dc.rightsfechadopt_BR
dc.sourceWOSpt_BR
dc.identifier.issn1479-6694pt_BR
dc.identifier.eissn1744-8301pt_BR
dc.identifier.wosidWOS:000394416000005pt_BR
dc.identifier.doi10.2217/fon-2016-0299pt_BR
dc.identifier.urlhttps://www.futuremedicine.com/doi/abs/10.2217/fon-2016-0299pt_BR
dc.description.sponsorshipSao Paulo Research Foundation (FAPESP) [06/01710-8]pt_BR
dc.description.sponsorship1Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP)pt_BR
dc.date.available2017-11-13T13:21:30Z-
dc.date.accessioned2017-11-13T13:21:30Z-
dc.description.provenanceMade available in DSpace on 2017-11-13T13:21:30Z (GMT). No. of bitstreams: 0 Previous issue date: 2017en
dc.identifier.urihttp://repositorio.unicamp.br/jspui/handle/REPOSIP/327767-
Appears in Collections:Unicamp - Artigos e Outros Documentos

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