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Type: Artigo
Title: Chemical Composition Of The Essential Oil From The Leaves Of Anaxagorea Brevipes (annonaceae) And Evaluation Of Its Bioactivity
Author: de Alencar
Danielle Cardoso; Belem Pinheiro
Maria Lucia; da Silva Pereira
Jose Lamak; de Carvalho
Joao Ernesto; Campos
Francinete Ramos; Serain
Alessandra Freitas; Tirico
Ricardo Brunelli; Hernandez-Tasco
Alvaro Jose; Costa
Emmanoel Vilaca; Salvador
Marcos Jose
Abstract: The essential oil obtained by hydrodistillation from leaves of Anaxagorea brevipes was analysed by gas chromatography fitted with a flame ionisation detector (GC-FID) and coupled to mass spectrometry (GC-MS). Thirty one components were identified, representing around 75.7% of total oil. The major components were -eudesmol (13.16%), -eudesmol (13.05%), -eudesmol (7.54%), guaiol (5.12%), Caryophyllene oxide (4.18%) and -bisabolene (4.10%). The essential oil showed antimicrobial activity against Gram-positive bacteria and yeast with the MIC values between 25.0 and 100g/mL. The highest antiproliferative activity was observed for the oil against MCF-7 (breast, TGI=12.8g/mL), NCI-H460 (lung, TGI=13.0g/mL) and PC-3 (prostate, TGI=9.6g/mL) cell lines, while against no cancer cell line HaCat (keratinocyte) the TGI was 38.8g/mL. The oil exhibited a small antioxidant activity assessed through ORAC-FL assay (517molTE/g). This is the first report regarding the chemical composition and bioactivity of A. brevipes essential oil.
Subject: Anaxagorea Brevipes
Essential Oil
Editor: Taylor & Francis Ltd
Citation: Natural Product Research. Taylor & Francis Ltd, v. 30, p. 1088 - 1092, 2016.
Rights: fechado
Identifier DOI: 10.1080/14786419.2015.1101103
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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