Please use this identifier to cite or link to this item: http://repositorio.unicamp.br/jspui/handle/REPOSIP/327753
Type: Artigo
Title: The Total Synthesis Of Calcium Atorvastatin
Author: Dias
Luiz C.; Vieira
Adriano S.; Barreiro
Eliezer J.
Abstract: A practical and convergent asymmetric route to calcium atorvastatin (1) is reported. The synthesis of calcium atorvastatin (1) was performed using the remote 1,5-anti asymmetric induction in the boron-mediated aldol reaction of beta-alkoxy methylketone (4) with pyrrolic aldehyde (3) as a key step. Calcium atorvastatin was obtained from aldehyde (3) after 6 steps, with a 41% overall yield.
Editor: Royal Soc Chemistry
Cambrigde
Rights: fechado
Identifier DOI: 10.1039/c5ob02546j
Address: http://pubs.rsc.org/en/Content/ArticleLanding/2016/OB/C5OB02546J#!divAbstract
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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