Please use this identifier to cite or link to this item:
http://repositorio.unicamp.br/jspui/handle/REPOSIP/327740
Type: | Artigo |
Title: | Effects Of Novel Acylhydrazones Derived From 4-quinolone On The Acetylcholinesterase Activity And A Beta 42 Peptide Fibrils Formation Effects of novel acylhydrazones derived from 4-quinolone on the acetylcholinesterase activity and Aβ42 peptide fibrils formation |
Author: | Silva, Gisele S. da Figueiró, Micheli Tormena, Cláudio F. Coelho, Fernando Almeida, Wanda P. |
Abstract: | Acetylcholinesterase inhibitors and compounds that trigger Ab amyloid oligomerization and fibrillization represent an opportunity to discover new drug candidates to treat Alzheimer's disease. In this work, we synthesized nine new acylhydrazones and a known one, both employing 3-carboethoxy-4-quinolone derivatives as starting materials with chemical yields ranging from 63% to 90%. We evaluated the effect of these compounds on the acetylcholinesterase (AChE) activity and the fibrillization of A beta(42) peptide. Except for one acylhydrazone, the compounds exhibited good inhibitory effect on AChE (1.2 mu M < IC50 values < 17 mu M). They also showed a significant decrease in the thioflavin-T fluorescence emission, suggesting an inhibitory effect on the A beta(42) fibril formation. Acetylcholinesterase inhibitors and compounds that trigger Aβ amyloid oligomerization and fibrillization represent an opportunity to discover new drug candidates to treat Alzheimer’s disease. In this work, we synthesized nine new acylhydrazones and a know |
Subject: | Acetylcholinesterase Acylhydrazone Alzheimer's Disease Beta-amyloid Quinolone Acetilcolinesterase Alzheimer, Doença de Beta-amiloide Quinolonas |
Country: | Reino Unido |
Editor: | Taylor & Francis |
Citation: | Journal Of Enzyme Inhibition And Medicinal Chemistry. Taylor & Francis Ltd, v. 31, p. 1464 - 1470, 2016. |
Rights: | fechado |
Identifier DOI: | 10.3109/14756366.2016.1144597 |
Address: | https://www.tandfonline.com/doi/full/10.3109/14756366.2016.1144597 |
Date Issue: | 2016 |
Appears in Collections: | IQ - Artigos e Outros Documentos FCF - Artigos e Outros Documentos |
Files in This Item:
File | Size | Format | |
---|---|---|---|
000385270300077.pdf | 770.72 kB | Adobe PDF | View/Open |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.