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Type: Artigo
Title: Comparative Genomics Reveals High Biological Diversity And Specific Adaptations In The Industrially And Medically Important Fungal Genus Aspergillus
Author: de Vries
Ronald P.; Riley
Robert; Wiebenga
Ad; Aguilar-Osorio
Guillermo; Amillis
Sotiris; Uchima
Cristiane Akemi; Anderluh
Gregor; Asadollahi
Mojtaba; Askin
Marion; Barry
Kerrie; Battaglia
Evy; Bayram
Ozgur; Benocci
Tiziano; Braus-Stromeyer
Susanna A.; Caldana
Camila; Canovas
David; Cerqueira
Gustavo C.; Chen
Fusheng; Chen
Wanping; Choi
Cindy; Clum
Alicia; Correa dos Santos
Renato Augusto; de Lima Damasio
Andre Ricardo; Diallinas
George; Emri
Tamas; Fekete
Erzsebet; Flipphi
Michel; Freyberg
Susanne; Gallo
Antonia; Gournas
Christos; Habgood
Rob; Hainaut
Matthieu; Laura Harispe
Maria; Henrissat
Bernard; Hilden
Kristiina S.; Hope
Ryan; Hossain
Abeer; Karabika
Eugenia; Karaffa
Levente; Karanyi
Zsolt; Krasevec
Nada; Kuo
Alan; Kusch
Harald; LaButti
Kurt; Lagendijk
Ellen L.; Lapidus
Alla; Levasseur
Anthony; Lindquist
Erika; Lipzen
Anna; Logrieco
Antonio F.; MacCabe
Andrew; Makela
Miia R.; Malavazi
Iran; Melin
Petter; Meyer
Vera; Mielnichuk
Natalia; Miskei
Marton; Molnar
Akos P.; Mule
Giuseppina; Ngan
Chew Yee; Orejas
Margarita; Orosz
Erzsebet; Ouedraogo
Jean Paul; Overkamp
Karin M.; Park
Hee-Soo; Perrone
Giancarlo; Piumi
Francois; Punt
Peter J.; Ram
Arthur F. J.; Ramon
Ana; Rauscher
Stefan; Record
Eric; Riano-Pachon
Diego Mauricio; Robert
Vincent; Roehrig
Julian; Ruller
Roberto; Salamov
Asaf; Salih
Nadhira S.; Samson
Rob A.; Sandor
Erzsebet; Sanguinetti
Manuel; Schutze
Tabea; Sepcic
Kristina; Shelest
Ekaterina; Sherlock
Gavin; Sophianopoulou
Vicky; Squina
FabioM.; Sun
Hui; Susca
Antonia; Todd
Richard B.; Tsang
Adrian; Unkles
Shiela E.; van de Wiele
Nathalie; van Rossen-Uffink
Diana; de Castro Oliveira
Juliana Velasco; Vesth
Tammi C.; Visser
Jaap; Yu
Jae-Hyuk; Zhou
Miaomiao; Andersen
Mikael R.; Archer
David B.; Baker
Scott E.; Benoit
Isabelle; Brakhage
Axel A.; Braus
Gerhard H.; Fischer
Reinhard; Frisvad
Jens C.; Goldman
Gustavo H.; Houbraken
Jos; Oakley
Berl; Pocsi
Istvan; Scazzocchio
Claudio; Seiboth
Bernhard; vanKuyk
Patricia A.; Wortman
Jennifer; Dyer
Paul S.; Grigoriev
Igor V.
Abstract: The fungal genus Aspergillus is of critical importance to humankind. Species include those with industrial applications, important pathogens of humans, animals and crops, a source of potent carcinogenic contaminants of food, and an important genetic model. The genome sequences of eight aspergilli have already been explored to investigate aspects of fungal biology, raising questions about evolution and specialization within this genus. Results: We have generated genome sequences for ten novel, highly diverse Aspergillus species and compared these in detail to sister and more distant genera. Comparative studies of key aspects of fungal biology, including primary and secondary metabolism, stress response, biomass degradation, and signal transduction, revealed both conservation and diversity among the species. Observed genomic differences were validated with experimental studies. This revealed several highlights, such as the potential for sex in asexual species, organic acid production genes being a key feature of black aspergilli, alternative approaches for degrading plant biomass, and indications for the genetic basis of stress response. A genome-wide phylogenetic analysis demonstrated in detail the relationship of the newly genome sequenced species with other aspergilli. Conclusions: Many aspects of biological differences between fungal species cannot be explained by current knowledge obtained from genome sequences. The comparative genomics and experimental study, presented here, allows for the first time a genus-wide view of the biological diversity of the aspergilli and in many, but not all, cases linked genome differences to phenotype. Insights gained could be exploited for biotechnological and medical applications of fungi.
Subject: Aspergillus
Genome Sequencing
Comparative Genomics
Fungal Biology
Editor: Biomed Central Ltd
Citation: Genome Biology. Biomed Central Ltd, v. 18, p. , 2017.
Rights: aberto
Identifier DOI: 10.1186/s13059-017-1151-0
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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