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Type: Artigo
Title: Metformin Treatment Modulates The Tumour-induced Wasting Effects In Muscle Protein Metabolism Minimising The Cachexia In Tumour-bearing Rats
Author: Oliveira
Andre G.; Gomes-Marcondes
Maria Cristina C.
Abstract: Cancer-cachexia state frequently induces both fat and protein wasting, leading to death. In this way, the knowledge of the mechanism of drugs and their side effects can be a new feature to treat and to have success, contributing to a better life quality for these patients. Metformin is an oral drug used in type 2 diabetes mellitus, showing inhibitory effect on proliferation in some neoplastic cells. For this reason, we evaluated its modulatory effect on Walker-256 tumour evolution and also on protein metabolism in gastrocnemius muscle and body composition. Methods: Wistar rats received or not tumour implant and metformin treatment and were distributed into four groups, as followed: control (C), Walker 256 tumour-bearing (W), metformin-treated (M) and tumour-bearing treated with metformin (WM). Animals were weighed three times a week, and after cachexia state has been detected, the rats were euthanised and muscle and tumour excised and analysed by biochemical and molecular assays. Results: Tumour growth promoted some deleterious effects on chemical body composition, increasing water and decreasing fat percentage, and reducing lean body mass. In muscle tissue, tumour led to a decreased protein synthesis and an increased proteolysis, showing the higher activity of the ubiquitin-proteasome pathway. On the other hand, the metformin treatment likely minimised the tumour-induced wasting state; in this way, this treatment ameliorated chemical body composition, reduced the higher activities of proteolytic enzymes and decreased the protein waste. Conclusion: Metformin treatment not only decreases the tumour growth but also improves the protein metabolism in gastrocnemius muscle in tumour-bearing rats.
Subject: Cancer
Protein Synthesis
Protein Degradation
Muscle Metabolism
Walker-256 Tumour
Editor: Biomed Central Ltd
Citation: Bmc Cancer. Biomed Central Ltd, v. 16, p. , 2016.
Rights: aberto
Identifier DOI: 10.1186/s12885-016-2424-9
Date Issue: 2016
Appears in Collections:Unicamp - Artigos e Outros Documentos

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