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Type: Artigo
Title: Clinical Relevance Of Breast And Gastric Cancer-associated Polymorphisms As Potential Susceptibility Markers For Oral Clefts In The Brazilian Population
Author: Machado
Renato Assis; de Freitas
Edimilson Martins; de Aquino
Sibele Nascimento; Martelli
Daniella Reis B.; Oliveira Swerts
Mario Sergio; de Almeida Reis
Silvia Regina; Persuhn
Darlene Camati; Bertolossi Moreira
Helenara Salvati; Dias
Veronica Oliveira; Coletta
Ricardo D.; Martelli-Junior
Abstract: Epidemiological studies have indicated a higher incidence of breast and gastric cancer in patients with nonsyndromic cleft lip with or without cleft palate (NSCL +/- P) and their relatives, which can be based on similar genetic triggers segregated within family with NSCL +/- P. Methods: This multicenter study evaluated the association of 9 single nucleotide polymorphisms (SNP) in AXIN2 and CDH1, representing genes consistently altered in breast and gastric tumors, with NSCL +/- P in 223 trios (father, mother and patient with NSCL +/- P) by transmission disequilibrium test (TDT). Results: Our results showed that the minor A allele of rs7210356 (p = 0.01) and the T-G-G-A-G haplotype formed by rs7591, rs7210356, rs4791171, rs11079571 and rs3923087 SNPs (p = 0.03) in AXIN2 were significantly under-transmitted to patients with NSCL +/- P. In CDH1 gene, the C-G-A-A and A-G-A-G haplotypes composed by rs16260, rs9929218, rs7186053 and rs4783573 polymorphisms were respectively over-transmitted (p = 0.01) and under-transmitted (p = 0.008) from parents to the children with NSCL +/- P. Conclusions: The results suggest that polymorphic variants in AXIN2 and CDH1 may be associated with NSCL +/- P susceptibility, and reinforce the putative link between cancer and oral clefts.
Subject: Nonsyndromic Cleft Lip With Or Without Cleft Palate
Breast Cancer
Gastric Cancer
Editor: Biomed Central Ltd
Rights: aberto
Identifier DOI: 10.1186/s12881-017-0390-y
Date Issue: 2017
Appears in Collections:Unicamp - Artigos e Outros Documentos

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